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Gaurav K, Goel RK, Shukla M, et al. Glutamine: A novel approach to chemotherapy-induced toxicity. Indian J Med Paediatr Oncol. 2012;33(1):13-20doi: 10.4103/0971-5851.96962.
Gaurav, K., Goel, R. K., Shukla, M., & Pandey, M. (2012). Glutamine: A novel approach to chemotherapy-induced toxicity. Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology, 33(1), 13-20. https://doi.org/10.4103/0971-5851.96962
Gaurav, Kumar, et al. "Glutamine: A novel approach to chemotherapy-induced toxicity." Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology vol. 33,1 (2012): 13-20. doi: https://doi.org/10.4103/0971-5851.96962
Gaurav K, Goel RK, Shukla M, Pandey M. Glutamine: A novel approach to chemotherapy-induced toxicity. Indian J Med Paediatr Oncol. 2012 Jan;33(1):13-20. doi: 10.4103/0971-5851.96962. PMID: 22754203; PMCID: PMC3385273.
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Indian J Med Paediatr Oncol. 2012 Jan;33(1):13-20. doi: 10.4103/0971-5851.96962.

Glutamine: A novel approach to chemotherapy-induced toxicity.

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology

Kumar Gaurav, R K Goel, Mridula Shukla, Manoj Pandey

Affiliations

  1. Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

PMID: 22754203 PMCID: PMC3385273 DOI: 10.4103/0971-5851.96962

Abstract

Treatment of cancer is associated with short- and long-term side-effects. Cancer produces a state of glutamine deficiency, which is further aggravated by toxic effects of chemotherapeutic agents leading to increased tolerance of tumor to chemotherapy as well as reduced tolerance of normal tissues to the side-effects of chemotherapy. This article reviews the possible role of glutamine supplementation in reducing the serious adverse events in patients treated with anticancer drugs. The literature related to the possible role of glutamine in humans with cancer and the supportive evidence from animal studies was reviewed. Searches were made and the literature was retrieved using PUBMED, MEDLINE, COCHRANE LIBRARY, CENAHL and EMBASE, with a greater emphasis on the recent advances and clinical trials. Glutamine supplementation was found to protect against radiation-induced mucositis, anthracycline-induced cardiotoxicity and paclitaxel-related myalgias/arthralgias. Glutamine may prevent neurotoxicity of paclitaxel, cisplatin, oxaplatin bortezomib and lenolidamide, and is beneficial in the reduction of the dose-limiting gastrointestinal toxic effects of irinotecan and 5-FU-induced mucositis and stomatitis. Dietary glutamine reduces the severity of the immunosuppressive effect induced by methotrexate and improves the immune status of rats recovering from chemotherapy. In patients with acute myeloid leukemia requiring parenteral nutrition, glycyl-glutamine supplementation could hasten neutrophil recovery after intensive myelosuppressive chemotherapy. Current data supports the usefulness of glutamine supplementation in reducing complications of chemotherapy; however, paucity of clinical trials weakens the clear interpretation of these findings.

Keywords: Cancer; chemotherapy; glutamine; toxicity

References

  1. JPEN J Parenter Enteral Nutr. 1992 Nov-Dec;16(6 Suppl):83S-87S - PubMed
  2. Oral Oncol. 1999 Sep;35(5):453-70 - PubMed
  3. JPEN J Parenter Enteral Nutr. 1993 May-Jun;17(3):299-300 - PubMed
  4. Oncologist. 2007 Mar;12(3):312-9 - PubMed
  5. Cancer Treat Rep. 1977 Aug;61(5):797-804 - PubMed
  6. Ann Surg. 1995 Jan;221(1):50-8 - PubMed
  7. J Surg Res. 1990 Apr;48(4):319-23 - PubMed
  8. Br J Nutr. 2002 Jan;87 Suppl 1:S9-15 - PubMed
  9. J Cell Physiol. 1994 Dec;161(3):589-96 - PubMed
  10. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9701-5 - PubMed
  11. N Engl J Med. 1988 Sep 22;319(12):745-52 - PubMed
  12. Am J Physiol. 1998 May;274(5):E817-26 - PubMed
  13. Cancer Lett. 1996 Jul 19;105(1):29-32 - PubMed
  14. Am J Clin Nutr. 2002 Feb;75(2):183-90 - PubMed
  15. Nutr Rev. 1990 Aug;48(8):297-309 - PubMed
  16. J Clin Oncol. 2003 May 1;21(9):1669-74 - PubMed
  17. Ann Surg. 1995 Apr;221(4):420-6 - PubMed
  18. Arch Surg. 1992 Oct;127(10):1237-40 - PubMed
  19. Surgery. 1994 Aug;116(2):356-65; discussion 365-6 - PubMed
  20. J Cancer Res Clin Oncol. 2001 May;127(5):314-8 - PubMed
  21. J Appl Physiol (1985). 2001 Jun;90(6):2403-10 - PubMed
  22. JPEN J Parenter Enteral Nutr. 2003 Nov-Dec;27(6):396-403 - PubMed
  23. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5750-5 - PubMed
  24. J Surg Res. 1999 Jul;85(1):178-82 - PubMed
  25. Cancer Res. 1981 Sep;41(9 Pt 1):3584-91 - PubMed
  26. Metabolism. 1989 Aug;38(8 Suppl 1):63-6 - PubMed
  27. Clin Nutr. 2007 Feb;26(1):57-62 - PubMed
  28. Kidney Int. 1999 Mar;55(3):778-92 - PubMed
  29. Ann Surg. 1997 Jan;225(1):112-21 - PubMed
  30. Cancer Lett. 1991 Jul 4;58(3):221-4 - PubMed
  31. Metabolism. 1995 Sep;44(9):1215-22 - PubMed
  32. Cancer Treat Rep. 1977 Aug;61(5):779-83 - PubMed
  33. Am J Surg. 1996 Nov;172(5):418-24 - PubMed
  34. Ann Surg. 1992 Feb;215(2):107-13 - PubMed
  35. Ann Surg. 1998 May;227(5):772-8; discussion 778-80 - PubMed
  36. Eur J Cancer. 1999 Feb;35(2):202-7 - PubMed
  37. J Nutr. 2000 Apr;130(4S Suppl):995S-1001S - PubMed
  38. Am J Physiol. 1987 Dec;253(6 Pt 2):F1069-76 - PubMed
  39. Cancer Treat Rev. 1991 Dec;18(4):241-52 - PubMed
  40. Ann Surg. 1980 Jul;192(1):78-85 - PubMed
  41. Am J Surg. 1992 Jan;163(1):174-9; discussion 179-80 - PubMed
  42. Life Sci. 1981 Oct 5;29(14):1393-401 - PubMed
  43. J Trauma. 1996 May;40(5):688-92; discussion 692-3 - PubMed
  44. Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1330-7 - PubMed
  45. Cancer. 1985 Jan 1;55(1 Suppl):230-7 - PubMed
  46. Cancer. 1994 Nov 15;74(10):2879-84 - PubMed
  47. Int J Biochem. 1990;22(7):681-3 - PubMed
  48. Ann Intern Med. 1992 May 15;116(10):821-8 - PubMed
  49. Cancer Res. 1988 Mar 15;48(6):1551-3 - PubMed
  50. Mol Genet Metab. 1999 Jun;67(2):100-5 - PubMed
  51. Bone Marrow Transplant. 1998 Aug;22(3):281-4 - PubMed
  52. J Oncol Pharm Pract. 2007 Dec;13(4):181-98 - PubMed
  53. Arch Surg. 1991 Jan;126(1):23-7 - PubMed
  54. Ann Surg Oncol. 1995 Jan;2(1):71-6 - PubMed
  55. Bone Marrow Transplant. 1998 Aug;22(4):339-44 - PubMed
  56. J Pharm Pharmacol. 1986 Apr;38(4):277-82 - PubMed
  57. Nutrition. 2004 Mar;20(3):249-54 - PubMed
  58. Z Naturforsch C J Biosci. 1988 Sep-Oct;43(9-10):793-4 - PubMed
  59. Ann Surg Oncol. 1994 Mar;1(2):157-63 - PubMed
  60. Immunobiology. 1986 Oct;173(1):23-34 - PubMed
  61. Am J Physiol. 1997 Dec;273(6):L1182-90 - PubMed
  62. Gastroenterology. 1994 Aug;107(2):429-34 - PubMed
  63. Bone Marrow Transplant. 1998 Apr;21(8):829-32 - PubMed
  64. Cancer Res. 1972 Feb;32(2):326-33 - PubMed
  65. Clin Nutr. 1995 Jun;14(3):162-5 - PubMed
  66. J Bioenerg Biomembr. 1991 Aug;23(4):689-97 - PubMed
  67. JPEN J Parenter Enteral Nutr. 1988 Jul-Aug;12(4):325-31 - PubMed
  68. J Am Diet Assoc. 1994 Nov;94(11):1263-6 - PubMed
  69. J Surg Res. 1988 Jun;44(6):720-6 - PubMed
  70. J Trauma. 1992 May;32(5):600-6; discussion 606-7 - PubMed
  71. J Mol Cell Cardiol. 1998 Nov;30(11):2319-25 - PubMed
  72. Surgery. 1997 Aug;122(2):451-63; discussion 463-4 - PubMed
  73. Adv Cancer Res. 1979;30:89-150 - PubMed
  74. Mol Cell Biochem. 1992 Jul 6;113(1):1-15 - PubMed
  75. JPEN J Parenter Enteral Nutr. 2000 Mar-Apr;24(2):61-6 - PubMed
  76. Clin Oncol (R Coll Radiol). 2005 Jun;17(4):271-6 - PubMed
  77. Nutrition. 2003 Sep;19(9):805-11 - PubMed
  78. JPEN J Parenter Enteral Nutr. 1994 Nov-Dec;18(6):471-6 - PubMed
  79. JPEN J Parenter Enteral Nutr. 1995 Nov-Dec;19(6):492-7 - PubMed
  80. Ann Surg. 1993 Dec;218(6):715-28 - PubMed
  81. Curr Opin Clin Nutr Metab Care. 1999 Jul;2(4):323-7 - PubMed
  82. J Lab Clin Med. 1996 Feb;127(2):223-8 - PubMed
  83. JPEN J Parenter Enteral Nutr. 1993 Sep-Oct;17(5):407-13 - PubMed
  84. Lancet. 1990 Sep 1;336(8714):523-5 - PubMed
  85. J Appl Physiol. 1974 Jun;36(6):693-7 - PubMed
  86. Cancer. 1990 Jul 1;66(1):62-8 - PubMed
  87. Altern Med Rev. 1999 Aug;4(4):239-48 - PubMed
  88. Gut. 2001 Jan;48(1):28-33 - PubMed
  89. J Nutr. 2001 Sep;131(9 Suppl):2578S-84S; discussion 2590S - PubMed
  90. Nutrition. 2004 Oct;20(10):934-41 - PubMed
  91. J Clin Invest. 1981 Oct;68(4):1053-64 - PubMed
  92. J Surg Res. 1993 May;54(5):393-400 - PubMed
  93. Ann Surg. 1990 May;211(5):543-9; discussion 549-51 - PubMed
  94. Cancer Res. 1984 Sep;44(9):3831-5 - PubMed

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