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Shin JY, Park EK, Park BJ, et al. High-normal Glucose Levels in Non-diabetic and Pre-diabetic Men Are Associated with Decreased Testosterone Levels. Korean J Fam Med. 2012;33(3):152-6doi: 10.4082/kjfm.2012.33.3.152.
Shin, J. Y., Park, E. K., Park, B. J., Shim, J. Y., & Lee, H. R. (2012). High-normal Glucose Levels in Non-diabetic and Pre-diabetic Men Are Associated with Decreased Testosterone Levels. Korean journal of family medicine, 33(3), 152-6. https://doi.org/10.4082/kjfm.2012.33.3.152
Shin, Jin Young, et al. "High-normal Glucose Levels in Non-diabetic and Pre-diabetic Men Are Associated with Decreased Testosterone Levels." Korean journal of family medicine vol. 33,3 (2012): 152-6. doi: https://doi.org/10.4082/kjfm.2012.33.3.152
Shin JY, Park EK, Park BJ, Shim JY, Lee HR. High-normal Glucose Levels in Non-diabetic and Pre-diabetic Men Are Associated with Decreased Testosterone Levels. Korean J Fam Med. 2012 May;33(3):152-6. doi: 10.4082/kjfm.2012.33.3.152. Epub 2012 May 24. PMID: 22787537; PMCID: PMC3391640.
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Korean J Fam Med. 2012 May;33(3):152-6. doi: 10.4082/kjfm.2012.33.3.152. Epub 2012 May 24.

High-normal Glucose Levels in Non-diabetic and Pre-diabetic Men Are Associated with Decreased Testosterone Levels.

Korean journal of family medicine

Jin Young Shin, Eun Ki Park, Byoung Jin Park, Jae Yong Shim, Hye Ree Lee

Affiliations

  1. Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

PMID: 22787537 PMCID: PMC3391640 DOI: 10.4082/kjfm.2012.33.3.152

Abstract

BACKGROUND: Testosterone levels are decreased in diabetic patients and recent studies have suggested that high-normal fasting glucose is a risk factor for cardiovascular disease. To further elucidate the relationship between plasma glucose and testosterone, we investigated the association between fasting plasma glucose (FPG) and endogenous sex hormones (serum total testosterone, sex hormone binding globulin, estradiol, and the ratio of testosterone to estradiol) in non-diabetic and pre-diabetic men.

METHODS: This study included 388 men (age ≥ 40 years) who visited the health promotion center of a university hospital from May 2007 to August 2008. The subjects were divided into quartiles based on their FPG levels and correlation and multiple linear regression analyses were performed. Q1 (65 mg/dL ≤ FPG < 88 mg/dL), Q2 (88 mg/dL ≤ FPG < 94 mg/dL), Q3 (94 mg/dL ≤ FPG < 100 mg/dL) and Q4 (100 mg/dL ≤ FPG < 126 mg/dL).

RESULTS: FPG was independently, inversely associated with total testosterone in the non-diabetic population after adjusting for age, body mass index, smoking, and alcohol consumption (β = -0.082, P < 0.01). Among the quartiles, subjects in the high-normal FPG groups (Q2, Q3, and Q4 with FPG ≥ 88 mg/dL) had significantly decreased testosterone levels when compared with subjects in the normal FPG group (Q1 with FPG < 88 mg/dL, P < 0.005). Sex hormone binding globulin, estradiol and the ratio of testosterone to estradiol were not correlated with FPG.

CONCLUSION: Our study indicates that high-normal fasting glucose levels are associated with decreased testosterone levels in non-diabetic and pre-diabetic men.

Keywords: Glucose; Gonadal Steroid Hormones; Testosterone

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