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Sumigray KD, Lechler T. Control of cortical microtubule organization and desmosome stability by centrosomal proteins. Bioarchitecture. 2011;1(5):221-224doi: 10.4161/bioa.18403.
Sumigray, K. D., & Lechler, T. (2011). Control of cortical microtubule organization and desmosome stability by centrosomal proteins. Bioarchitecture, 1(5), 221-224. https://doi.org/10.4161/bioa.18403
Sumigray, Kaelyn D, and Lechler, Terry. "Control of cortical microtubule organization and desmosome stability by centrosomal proteins." Bioarchitecture vol. 1,5 (2011): 221-224. doi: https://doi.org/10.4161/bioa.18403
Sumigray KD, Lechler T. Control of cortical microtubule organization and desmosome stability by centrosomal proteins. Bioarchitecture. 2011 Sep 01;1(5):221-224. doi: 10.4161/bioa.18403. PMID: 22754612; PMCID: PMC3384573.
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Bioarchitecture. 2011 Sep 01;1(5):221-224. doi: 10.4161/bioa.18403.

Control of cortical microtubule organization and desmosome stability by centrosomal proteins.

Bioarchitecture

Kaelyn D Sumigray, Terry Lechler

PMID: 22754612 PMCID: PMC3384573 DOI: 10.4161/bioa.18403

Abstract

In many tissues microtubules reorganize into non-centrosomal arrays in differentiated cells. In the epidermis, proliferative basal cells have a radial array of microtubules organized around a centrosome, while differentiated cells have cortical microtubules. The desmosomal protein desmoplakin is required for the microtubules to organize around the cell cortex. Furthermore, the centrosomal and/or microtubule-associated proteins ninein, Lis1, Ndel1, and CLIP170 are recruited to the cell cortex, where they have been implicated in the cortical organization of microtubules. Recently, it has been shown that in Lis1-null epidermis, microtubules are disorganized in the differentiated layers of the epidermis. Furthermore, Lis1-null mice die perinatally due to dehydration. This is due, in part, to the unexpected desmosome phenotype observed in Lis1-null skin. Upon loss of Lis1, desmosomal proteins become less stable. Here, we propose that Lis1 may regulate desmosomal stability through its binding partners Nde1/Ndel1 and dynein.

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