Singapore Med J. 1990 Oct;31(5):474-6.

Cardiovascular malformations in Malaysian neonates with Down's syndrome.

Singapore medical journal

T S Hoe, K C Chan, N Y Boo

PMID: 2148028

Abstract

A prospective study was done to determine the incidence of cardiovascular malformations in neonates with Down's syndrome. 17/34 (50%) of the babies with Down's syndrome born at the Maternity Hospital, Kuala Lumpur, Malaysia had congenital heart defects. These included 7 cases of ventricular septal defect (VSD), 3 cases of patent ductus arteriosus (PDA), 2 cases of atrio-ventricular canal defect, 2 cases of ventricular septal defect with patent ductus arteriosus, 1 case of hypertrophic cardiomyopathy, 1 case of hypertrophic obstructive cardiomyopathy and 1 case of complex cyanotic heart. Only 8/17 (47%) of these babies had any clinical signs suggesting underlying cardiac defects. In view of the common occurrence of cardiac anomalies, it is recommended that echocardiographic screening should be carried out on all neonates with Down's syndrome.

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MeSH terms

• Down Syndrome / complications
• Heart Defects, Congenital / complications
• Humans
• Infant, Newborn
• Prospective Studies

Publication Types

• Journal Article

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