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Caselli D, Paolicchi O. Empiric antibiotic therapy in a child with cancer and suspected septicemia. Pediatr Rep. 2012;4(1):e2doi: 10.4081/pr.2012.e2.
Caselli, D., & Paolicchi, O. (2012). Empiric antibiotic therapy in a child with cancer and suspected septicemia. Pediatric reports, 4(1), e2. https://doi.org/10.4081/pr.2012.e2
Caselli, Desiree, and Paolicchi, Olivia. "Empiric antibiotic therapy in a child with cancer and suspected septicemia." Pediatric reports vol. 4,1 (2012): e2. doi: https://doi.org/10.4081/pr.2012.e2
Caselli D, Paolicchi O. Empiric antibiotic therapy in a child with cancer and suspected septicemia. Pediatr Rep. 2012 Jan 02;4(1):e2. doi: 10.4081/pr.2012.e2. Epub 2012 Jan 03. PMID: 22690308; PMCID: PMC3357615.
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Pediatr Rep. 2012 Jan 02;4(1):e2. doi: 10.4081/pr.2012.e2. Epub 2012 Jan 03.

Empiric antibiotic therapy in a child with cancer and suspected septicemia.

Pediatric reports

Desiree Caselli, Olivia Paolicchi

Affiliations

  1. Department Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Meyer Children Hospital, Firenze, Italy.

PMID: 22690308 PMCID: PMC3357615 DOI: 10.4081/pr.2012.e2

Abstract

Improved outcome in the treatment of childhood cancer results not only from more aggressive and tailored cancer-directed therapy, but also from improved supportive therapy and treatment of life-threatening infectious complications. Prompt and aggressive intervention with empiric antibiotics has reduced mortality in this group of patients. Physical examination, blood tests, and blood cultures must be performed, and antibiotic therapy must be administered as soon as possible. Beta-lactam monotherapy, such as piperacillin-tazobactam or cefepime, may be an appropriate empiric therapy of choice for all clinically stable patients with neutropenic fever. An anti-pseudomonal beta-lactam antibiotic plus gentamicin is recommended for patients with systemic compromise.

Keywords: antibiotic therapy; cancer.; child

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