Display options
Cite
von Känel R, Mausbach BT, Dimsdale JE, et al. Ways of coping and biomarkers of an increased atherothrombotic cardiovascular disease risk in elderly individuals. Cardiovasc Psychiatry Neurol. 2012;2012:875876doi: 10.1155/2012/875876.
von Känel, R., Mausbach, B. T., Dimsdale, J. E., Mills, P. J., Patterson, T. L., Ancoli-Israel, S., Ziegler, M. G., Roepke, S. K., Allison, M., & Grant, I. (2012). Ways of coping and biomarkers of an increased atherothrombotic cardiovascular disease risk in elderly individuals. Cardiovascular psychiatry and neurology, 2012875876. https://doi.org/10.1155/2012/875876
von Känel, Roland, et al. "Ways of coping and biomarkers of an increased atherothrombotic cardiovascular disease risk in elderly individuals." Cardiovascular psychiatry and neurology vol. 2012 (2012): 875876. doi: https://doi.org/10.1155/2012/875876
von Känel R, Mausbach BT, Dimsdale JE, Mills PJ, Patterson TL, Ancoli-Israel S, Ziegler MG, Roepke SK, Allison M, Grant I. Ways of coping and biomarkers of an increased atherothrombotic cardiovascular disease risk in elderly individuals. Cardiovasc Psychiatry Neurol. 2012;2012:875876. doi: 10.1155/2012/875876. Epub 2012 Jul 17. PMID: 22848795; PMCID: PMC3405559.
Copy Download .nbib Format: NLM
Share it on

Cardiovasc Psychiatry Neurol. 2012;2012:875876. doi: 10.1155/2012/875876. Epub 2012 Jul 17.

Ways of coping and biomarkers of an increased atherothrombotic cardiovascular disease risk in elderly individuals.

Cardiovascular psychiatry and neurology

Roland von Känel, Brent T Mausbach, Joel E Dimsdale, Paul J Mills, Thomas L Patterson, Sonia Ancoli-Israel, Michael G Ziegler, Susan K Roepke, Matthew Allison, Igor Grant

Affiliations

  1. Division of Psychosomatic Medicine, Department of General Internal Medicine, Bern University Hospital and University of Bern, 3010 Bern, Switzerland.

PMID: 22848795 PMCID: PMC3405559 DOI: 10.1155/2012/875876

Abstract

Objective. To investigate the relationship between coping and atherothrombotic biomarkers of an increased cardiovascular disease (CVD) risk in the elderly. Methods. We studied 136 elderly caregiving and noncaregiving men and women who completed the Ways of Coping Checklist to assess problem-focused coping, seeking social support (SSS), blamed self, wishful thinking, and avoidance coping. They had circulating levels of 12 biomarkers measured. We also probed for potential mediator and moderator variables (chronic stress, affect, health behavior, autonomic activity) for the relation between coping and biomarkers. Results. After controlling for demographic and CVD risk factors, greater use of SSS was associated with elevated levels of serum amyloid A (P = 0.001), C-reactive protein (CRP) (P = 0.002), vascular cellular adhesion molecule (VCAM)-1 (P = 0.021), and D-dimer (P = 0.032). There were several moderator effects. For instance, greater use of SSS was associated with elevated VCAM-1 (P < 0.001) and CRP (P = 0.001) levels in subjects with low levels of perceived social support and positive affect, respectively. The other coping styles were not significantly associated with any biomarker. Conclusions. Greater use of SSS might compromise cardiovascular health through atherothrombotic mechanisms, including elevated inflammation (i.e., serum amyloid A, CRP, VCAM-1) and coagulation (i.e., D-dimer) activity. Moderating variables need to be considered in this relationship.

References

  1. Dis Markers. 2009;26(5-6):217-25 - PubMed
  2. Health Psychol. 1988;7(3):269-97 - PubMed
  3. Hamostaseologie. 2009 Jan;29(1):32-8 - PubMed
  4. J Pers Soc Psychol. 1986 May;50(5):992-1003 - PubMed
  5. Int J Nurs Stud. 1997 Apr;34(2):151-63 - PubMed
  6. Psychiatry Res. 2006 Aug 30;143(2-3):223-34 - PubMed
  7. Multivariate Behav Res. 1985 Jan 1;20(1):3-26 - PubMed
  8. Psychosom Med. 2010 Apr;72(3):229-38 - PubMed
  9. Cardiovasc J Afr. 2010 Sep-Oct;21(5):268-73 - PubMed
  10. Intern Med J. 2003 Sep-Oct;33(9-10):450-62 - PubMed
  11. Circulation. 2006 May 16;113(19):2335-62 - PubMed
  12. J Behav Med. 2002 Dec;25(6):551-603 - PubMed
  13. Curr Vasc Pharmacol. 2006 Jul;4(3):205-13 - PubMed
  14. Gerontology. 2008;54(3):131-7 - PubMed
  15. Circulation. 2004 Jun 1;109(21 Suppl 1):II2-10 - PubMed
  16. Psychosom Med. 2009 Feb;71(2):171-86 - PubMed
  17. J Pers Soc Psychol. 1988 Jun;54(6):1063-70 - PubMed
  18. Neurosci Biobehav Rev. 2010 Sep;35(1):69-75 - PubMed
  19. Sleep. 1991 Aug;14(4):331-8 - PubMed
  20. Aging Ment Health. 2002 Aug;6(3):239-47 - PubMed
  21. Cardiovasc Res. 2009 Dec 1;84(3):353-60 - PubMed
  22. J Am Coll Cardiol. 2010 Jun 8;55(23):2599-606 - PubMed
  23. Arch Gen Psychiatry. 2007 Dec;64(12):1393-401 - PubMed
  24. J Thromb Haemost. 2005 Aug;3(8):1879-83 - PubMed
  25. Histopathology. 2007 Apr;50(5):535-46 - PubMed
  26. Psychol Bull. 2003 Nov;129(6):946-72 - PubMed
  27. Inflamm Res. 2010 May;59(5):323-34 - PubMed
  28. Psychol Bull. 2003 Mar;129(2):216-269 - PubMed
  29. Hypertension. 2003 Dec;42(6):1206-52 - PubMed
  30. Prev Chronic Dis. 2006 Oct;3(4):A118 - PubMed
  31. Semin Vasc Med. 2005 Nov;5(4):387-98 - PubMed
  32. Arteriosclerosis. 1990 Mar-Apr;10(2):263-75 - PubMed
  33. Am J Geriatr Psychiatry. 2008 Apr;16(4):310-7 - PubMed
  34. Nature. 2002 Dec 19-26;420(6917):868-74 - PubMed
  35. Psychiatry Res. 2008 Sep 30;160(3):247-55 - PubMed
  36. Circ Res. 2001 Oct 26;89(9):763-71 - PubMed
  37. Nat Rev Cardiol. 2009 Jun;6(6):410-7 - PubMed
  38. J Consult Clin Psychol. 1978 Oct;46(5):932-46 - PubMed
  39. Psychosom Med. 2002 May-Jun;64(3):418-35 - PubMed
  40. Life Sci. 1990;47(23):2143-53 - PubMed
  41. Pflugers Arch. 2010 May;459(6):951-8 - PubMed
  42. Gerontologist. 1990 Oct;30(5):583-94 - PubMed
  43. J Pediatr Psychol. 2002 Jan-Feb;27(1):87-96 - PubMed
  44. Int J Methods Psychiatr Res. 2004;13(3):141-51 - PubMed
  45. J Pers Soc Psychol. 1985 Jan;48(1):150-70 - PubMed
  46. BMC Immunol. 2009 Dec 08;10:62 - PubMed

Publication Types

Grant support