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Lin YY, Chou YL, Chu YH, et al. Effects of cromolyn sodium on isolated rat's trachea. Allergy Rhinol (Providence). 2011;2(2):e46-50doi: 10.2500/ar.2011.2.0015.
Lin, Y. Y., Chou, Y. L., Chu, Y. H., Wu, C. C., Wang, J. Y., & Wang, H. W. (2011). Effects of cromolyn sodium on isolated rat's trachea. Allergy & rhinology (Providence, R.I.), 2(2), e46-50. https://doi.org/10.2500/ar.2011.2.0015
Lin, Yuan-Yung, et al. "Effects of cromolyn sodium on isolated rat's trachea." Allergy & rhinology (Providence, R.I.) vol. 2,2 (2011): e46-50. doi: https://doi.org/10.2500/ar.2011.2.0015
Lin YY, Chou YL, Chu YH, Wu CC, Wang JY, Wang HW. Effects of cromolyn sodium on isolated rat's trachea. Allergy Rhinol (Providence). 2011 Apr;2(2):e46-50. doi: 10.2500/ar.2011.2.0015. PMID: 22852116; PMCID: PMC3390115.
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Allergy Rhinol (Providence). 2011 Apr;2(2):e46-50. doi: 10.2500/ar.2011.2.0015.

Effects of cromolyn sodium on isolated rat's trachea.

Allergy & rhinology (Providence, R.I.)

Yuan-Yung Lin, Ying-Liang Chou, Yueng-Hsiang Chu, Chi-Chung Wu, Jia-Yi Wang, Hsing-Won Wang

PMID: 22852116 PMCID: PMC3390115 DOI: 10.2500/ar.2011.2.0015

Abstract

Cromolyn sodium (cromolyn) effectively inhibits both antigen- and exercise-induced asthma when used as an aerosol. Intranasal cromolyn is also recommended for preventing and treating allergic rhinitis. By inhibiting the degranulation of sensitized mast cells, cromolyn reduces the release of mediators that trigger inflammation and the allergic response. The precise pharmacologic activity of cromolyn has not been fully elucidated. This study evaluated the effect of cromolyn on isolated rat's trachea. The following assessments of cromolyn were performed: (1) effect on tracheal resting tension, (2) effect on contraction caused by 10(-6) M of methacholine as a parasympathetic mimetic, and (3) effect of the drug on electrically induced tracheal contractions. The results indicated cromolyn could inhibit electrical field stimulation-induced spike contraction when the preparation was increased to 10(-4)M. Adding cromolyn at doses of ≥10(-8) M did not elicit a relaxation or contraction response to 10(-6) M of methacholine-induced contraction. It alone had a minimal effect on the basal tension of the trachea as the concentration increased. This study indicates cromolyn had no cholinergic or anticholinergic effect and high concentrations of cromolyn might actually inhibit parasympathetic function of the trachea. Inhibiting parasympathetic function of the trachea through stabilizing the presynaptic nerve by cromolyn may be responsible for protecting patients against antigen- and exercise-induced asthma.

Keywords: Cromolyn; in vitro study smooth muscle; trachea

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