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Delabranche X, Berger A, Boisramé-Helms J, et al. Microparticles and infectious diseases. Med Mal Infect. 2012;42(8):335-43doi: 10.1016/j.medmal.2012.05.011.
Delabranche, X., Berger, A., Boisramé-Helms, J., & Meziani, F. (2012). Microparticles and infectious diseases. Medecine et maladies infectieuses, 42(8), 335-43. https://doi.org/10.1016/j.medmal.2012.05.011
Delabranche, X, et al. "Microparticles and infectious diseases." Medecine et maladies infectieuses vol. 42,8 (2012): 335-43. doi: https://doi.org/10.1016/j.medmal.2012.05.011
Delabranche X, Berger A, Boisramé-Helms J, Meziani F. Microparticles and infectious diseases. Med Mal Infect. 2012 Aug;42(8):335-43. doi: 10.1016/j.medmal.2012.05.011. Epub 2012 Jul 04. PMID: 22766273.
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Med Mal Infect. 2012 Aug;42(8):335-43. doi: 10.1016/j.medmal.2012.05.011. Epub 2012 Jul 04.

Microparticles and infectious diseases.

Medecine et maladies infectieuses

X Delabranche, A Berger, J Boisramé-Helms, F Meziani

Affiliations

  1. Service de réanimation médicale, nouvel hôpital civil, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.

PMID: 22766273 DOI: 10.1016/j.medmal.2012.05.011

Abstract

Membrane shedding with microvesicle (MV) release after membrane budding due to cell stimulation is a highly conserved intercellular interplay. MV can be released by micro-organisms or by host cells in the course of infectious diseases. Host MVs are divided according to cell compartment origin in microparticles (MPs) from plasma membrane and exosomes from intracellular membranes. MPs are cell fragments resulting from plasma membrane reorganization characterized by phosphatidylserine (PhtdSer) content and parental cell antigens on membrane. The role of MPs in physiology and pathophysiology is not yet well elucidated; they are a pool of bioactive molecules able to transmit a pro-inflammatory message to neighboring or target cells. The first acknowledged function of MP was the dissemination of a procoagulant potential via PhtdSer and it is now obvious than MPs bear tissue factor (TF). Such MPs have been implicated in the coagulation disorders observed during sepsis and septic shock. MPs have been implicated in the regulation of vascular tone and cardiac dysfunction in experimental sepsis. Beside a non-specific role, pathogens such as Neisseria meningitidis and Ebola Virus can specifically activate blood coagulation after TF-bearing MPs release in the bloodstream with disseminated intravascular coagulopathy and Purpura fulminans. The role of MPs in host-pathogen interactions is also fundamental in Chagas disease, where MPs could allow immune evasion by inhibiting C3 convertase. During cerebral malaria, MPs play a complex role facilitating the activation of brain endothelium that contributes to amplify vascular obstruction by parasitized erythrocytes. Phagocytosis of HIV induced MPs expressing PhtdSer by monocytes/macrophages results in cellular infection and non-inflammatory response via up-regulation of TGF-β.

Copyright © 2012 Elsevier Masson SAS. All rights reserved.

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