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Mizushima J, Takahata K, Kawashima N, et al. Successful treatment of dopamine dysregulation syndrome with dopamine D2 partial agonist antipsychotic drug. Ann Gen Psychiatry. 2012;11(1):19doi: 10.1186/1744-859X-11-19.
Mizushima, J., Takahata, K., Kawashima, N., & Kato, M. (2012). Successful treatment of dopamine dysregulation syndrome with dopamine D2 partial agonist antipsychotic drug. Annals of general psychiatry, 11(1), 19. https://doi.org/10.1186/1744-859X-11-19
Mizushima, Jin, et al. "Successful treatment of dopamine dysregulation syndrome with dopamine D2 partial agonist antipsychotic drug." Annals of general psychiatry vol. 11,1 (2012): 19. doi: https://doi.org/10.1186/1744-859X-11-19
Mizushima J, Takahata K, Kawashima N, Kato M. Successful treatment of dopamine dysregulation syndrome with dopamine D2 partial agonist antipsychotic drug. Ann Gen Psychiatry. 2012 Jul 07;11(1):19. doi: 10.1186/1744-859X-11-19. PMID: 22769562; PMCID: PMC3465018.
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Ann Gen Psychiatry. 2012 Jul 07;11(1):19. doi: 10.1186/1744-859X-11-19.

Successful treatment of dopamine dysregulation syndrome with dopamine D2 partial agonist antipsychotic drug.

Annals of general psychiatry

Jin Mizushima, Keisuke Takahata, Noriko Kawashima, Motoichiro Kato

Affiliations

  1. Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. [email protected].

PMID: 22769562 PMCID: PMC3465018 DOI: 10.1186/1744-859X-11-19

Abstract

Dopamine dysregulation syndrome (DDS) consists of a series of complications such as compulsive use of dopaminergic medications, aggressive or hypomanic behaviors during excessive use, and withdrawal states characterized by dysphoria and anxiety, caused by long-term dopaminergic treatment in patients with Parkinson's disease (PD). Although several ways to manage DDS have been suggested, there has been no established treatment that can manage DDS without deterioration of motor symptoms. In this article, we present a case of PD in whom the administration of the dopamine D2 partial agonistic antipsychotic drug aripiprazole improved DDS symptoms such as craving and compulsive behavior without worsening of motor symptoms. Considering the profile of this drug as a partial agonist at D2 receptors, it is possible that it exerts its therapeutic effect on DDS by modulating the dysfunctional dopamine system.

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