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Cell. 2012 Aug 03;150(3):453-4. doi: 10.1016/j.cell.2012.07.015.

Exposing secrets of telomere-telomerase encounters.

Cell

Jean-François Noël, Raymund J Wellinger

Affiliations

  1. Department of Microbiology and Infectiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec J1E 4K8, Canada.

PMID: 22863000 DOI: 10.1016/j.cell.2012.07.015

Abstract

In order for telomeres to remain functional and stable, they must rendezvous with the enzyme telomerase in a productive manner. In human cells, this interaction is mediated by Cajal bodies as matchmaker, and now Zhong et al. reveal molecular determinants that establish good chemistry between the two partners.

Copyright © 2012 Elsevier Inc. All rights reserved.

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