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Li JJ, Yu KD, DI GH, et al. Clinicopathological features and treatment sensitivity of elderly Chinese breast cancer patients. Oncol Lett. 2010;1(6):1037-1043doi: 10.3892/ol.2010.179.
Li, J. J., Yu, K. D., DI, G. H., & Shao, Z. M. (2010). Clinicopathological features and treatment sensitivity of elderly Chinese breast cancer patients. Oncology letters, 1(6), 1037-1043. https://doi.org/10.3892/ol.2010.179
Li, Jun-Jie, et al. "Clinicopathological features and treatment sensitivity of elderly Chinese breast cancer patients." Oncology letters vol. 1,6 (2010): 1037-1043. doi: https://doi.org/10.3892/ol.2010.179
Li JJ, Yu KD, DI GH, Shao ZM. Clinicopathological features and treatment sensitivity of elderly Chinese breast cancer patients. Oncol Lett. 2010 Nov;1(6):1037-1043. doi: 10.3892/ol.2010.179. Epub 2010 Sep 23. PMID: 22870109; PMCID: PMC3412465.
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Oncol Lett. 2010 Nov;1(6):1037-1043. doi: 10.3892/ol.2010.179. Epub 2010 Sep 23.

Clinicopathological features and treatment sensitivity of elderly Chinese breast cancer patients.

Oncology letters

Jun-Jie Li, Ke-DA Yu, Gen-Hong DI, Zhi-Min Shao

Affiliations

  1. Department of Breast Surgery, Cancer Hospital/Cancer Institute, and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.

PMID: 22870109 PMCID: PMC3412465 DOI: 10.3892/ol.2010.179

Abstract

This study aimed to determine the clinicopathological features and treatment sensitivity of elderly breast cancer patients in China. The clinical data of 594 elderly breast cancer patients of 70 or more years of age were collected and compared to those of 657 patients of less than 70 years of age to analyze whether breast cancer in the elderly is different and whether the difference affected outcome. The median age was 75.2 years in the elderly patients and 49.8 years in the young patients. Age of menarche, parous status and body mass index were similar in the two groups. A higher frequency of steroid receptor-positive rate, a lower expression of HER-2 and p53, less axillary node-positive rate and earlier tumor stage were found in patients of 70 years or older. The 5-year relapse-free survival (RFS) and overall survival (OS) was 77 and 82% in the elderly and 86 and 93% in the young patients, respectively. Patients with estrogen receptor (ER)-positive or lymph node (LN)-negative cancers showed a more favorable outcome in the elderly patients. RFS and OS were increased in elderly patients who underwent endocrine therapy or omitted chemotherapy. Breast cancer in the elderly had more favorable tumor features, using estrogen receptor and lymph node status as prognostic factors. It was therefore concluded that adjuvant endocrine therapy may benefit elderly patients, while chemotherapy may not.

References

  1. Int J Cancer. 2007 Mar 15;120(6):1155-60 - PubMed
  2. J Clin Oncol. 2007 May 10;25(14):1858-69 - PubMed
  3. Ann Intern Med. 1994 Jan 15;120(2):104-10 - PubMed
  4. Hematol Oncol Clin North Am. 2000 Feb;14(1):213-34 - PubMed
  5. Eur J Surg Oncol. 1997 Aug;23(4):339-40 - PubMed
  6. Cancer. 2003 Mar 1;97(5):1156-63 - PubMed
  7. Eur J Cancer. 2007 Oct;43(15):2253-63 - PubMed
  8. J Clin Oncol. 2000 Apr;18(7):1412-22 - PubMed
  9. Oncologist. 2006 Nov-Dec;11(10):1081-8 - PubMed
  10. Crit Rev Oncol Hematol. 2003 Mar;45(3):313-25 - PubMed
  11. Am J Surg. 2006 Sep;192(3):317-21 - PubMed
  12. J Clin Oncol. 2006 Jan 20;24(3):337-44 - PubMed
  13. Crit Rev Oncol Hematol. 2003 May;46(2):115-20 - PubMed
  14. J Clin Oncol. 2003 Oct 1;21(19):3580-7 - PubMed
  15. Cancer. 2005 Nov 1;104(9):1998-2005 - PubMed
  16. Lancet. 2005 May 14-20;365(9472):1687-717 - PubMed
  17. Breast. 2004 Oct;13(5):369-75 - PubMed
  18. Crit Rev Oncol Hematol. 2003 May;46(2):121-6 - PubMed
  19. Eur J Cancer. 2007 Oct;43(15):2242-52 - PubMed
  20. J Clin Oncol. 2002 Jan 15;20(2):494-502 - PubMed
  21. J Clin Oncol. 2005 Dec 1;23(34):8597-605 - PubMed
  22. J Natl Cancer Inst. 2000 Apr 5;92(7):550-6 - PubMed
  23. J Clin Oncol. 2006 Sep 20;24(27):4377-83 - PubMed
  24. Crit Rev Oncol Hematol. 2008 Apr;66(1):75-83 - PubMed
  25. Surg Oncol. 2004 Dec;13(4):193-6 - PubMed
  26. Am J Epidemiol. 2000 Sep 15;152(6):514-27 - PubMed
  27. J Am Coll Surg. 1999 Jun;188(6):586-95; discussion 595-6 - PubMed
  28. Breast Cancer Res Treat. 2008 Jul;110(2):199-209 - PubMed
  29. Ann Oncol. 2004 Feb;15(2):207-10 - PubMed
  30. Int J Biochem Cell Biol. 2002 Nov;34(11):1318-30 - PubMed
  31. J Clin Oncol. 2000 Apr;18(8):1709-17 - PubMed
  32. Breast. 2007 Feb;16(1):60-7 - PubMed
  33. JAMA. 2003 Jul 2;290(1):27-8 - PubMed
  34. J Clin Oncol. 2002 Dec 15;20(24):4636-42 - PubMed
  35. Eur J Cancer. 2005 Jun;41(9):1267-77 - PubMed
  36. Breast J. 2006 Jul-Aug;12(4):353-9 - PubMed

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