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Badr M, Hassan T, Tarhony SE, et al. Insulin-like growth factor-1 and childhood cancer risk. Oncol Lett. 2010;1(6):1055-1059doi: 10.3892/ol.2010.169.
Badr, M., Hassan, T., Tarhony, S. E., & Metwally, W. (2010). Insulin-like growth factor-1 and childhood cancer risk. Oncology letters, 1(6), 1055-1059. https://doi.org/10.3892/ol.2010.169
Badr, Mohamed, et al. "Insulin-like growth factor-1 and childhood cancer risk." Oncology letters vol. 1,6 (2010): 1055-1059. doi: https://doi.org/10.3892/ol.2010.169
Badr M, Hassan T, Tarhony SE, Metwally W. Insulin-like growth factor-1 and childhood cancer risk. Oncol Lett. 2010 Nov;1(6):1055-1059. doi: 10.3892/ol.2010.169. Epub 2010 Sep 08. PMID: 22870112; PMCID: PMC3412533.
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Oncol Lett. 2010 Nov;1(6):1055-1059. doi: 10.3892/ol.2010.169. Epub 2010 Sep 08.

Insulin-like growth factor-1 and childhood cancer risk.

Oncology letters

Mohamed Badr, Tamer Hassan, Shereen El Tarhony, Wael Metwally

Affiliations

  1. Department of Pediatrics, Zagazig University, Zagazig, Egypt.

PMID: 22870112 PMCID: PMC3412533 DOI: 10.3892/ol.2010.169

Abstract

Overexpression of growth factors and/or their receptors is a common event in malignancy and provides the underlying mechanisms for one of the hallmarks of cancer, uncontrolled proliferation. Mounting evidence suggests that IGF-1 is involved in the pathogenesis and progression of different types of human cancer such as colon, breast, prostate and lung. However, only a few studies have investigated the association between IGF-1 levels and childhood cancer risk. We aimed to compare the IGF-1 serum level in children with de novo malignancies to healthy children, and to assess its relationship with cancer type, stage, metastasis and different disease characteristics. The study was carried out on 100 children; 50 children with de novo malignancies and 50 healthy children of matched age and gender as a control group. The patients were subjected to a routine work-up for their cancers according to our local standards. Estimation of the serum level of IGF-1 was carried out in the two groups using ELISA. Our results showed that children with cancer had significantly higher levels of IGF-1 than healthy controls of the same age and gender. No association was found between IGF-1 and tumor type, stage, metastasis and other disease characteristics. In conclusion, the IGF-1 serum level is an important indicator of risk for the most prevalent forms of childhood cancer. It may be used to identify children at the highest risk for these cancers and aid in determing who may benefit most from preventive strategies. Given the small number of children in our study, studies with larger populations are required to confirm these results.

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