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Seifer G, Blenkmann A, Princich JP, et al. Noninvasive approach to focal cortical dysplasias: clinical, EEG, and neuroimaging features. Epilepsy Res Treat. 2012;2012:736784doi: 10.1155/2012/736784.
Seifer, G., Blenkmann, A., Princich, J. P., Consalvo, D., Papayannis, C., Muravchik, C., & Kochen, S. (2012). Noninvasive approach to focal cortical dysplasias: clinical, EEG, and neuroimaging features. Epilepsy research and treatment, 2012736784. https://doi.org/10.1155/2012/736784
Seifer, Gustavo, et al. "Noninvasive approach to focal cortical dysplasias: clinical, EEG, and neuroimaging features." Epilepsy research and treatment vol. 2012 (2012): 736784. doi: https://doi.org/10.1155/2012/736784
Seifer G, Blenkmann A, Princich JP, Consalvo D, Papayannis C, Muravchik C, Kochen S. Noninvasive approach to focal cortical dysplasias: clinical, EEG, and neuroimaging features. Epilepsy Res Treat. 2012;2012:736784. doi: 10.1155/2012/736784. Epub 2012 Mar 05. PMID: 22957239; PMCID: PMC3420540.
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Epilepsy Res Treat. 2012;2012:736784. doi: 10.1155/2012/736784. Epub 2012 Mar 05.

Noninvasive approach to focal cortical dysplasias: clinical, EEG, and neuroimaging features.

Epilepsy research and treatment

Gustavo Seifer, Alejandro Blenkmann, Juan Pablo Princich, Damián Consalvo, Cristina Papayannis, Carlos Muravchik, Silvia Kochen

Affiliations

  1. Epilepsy Laboratory, IBCN, "Prof. E. De Robertis", School of Medicine, University of Buenos Aires, Paraguay 2155, 1121 Buenos Aires, Argentina.

PMID: 22957239 PMCID: PMC3420540 DOI: 10.1155/2012/736784

Abstract

Purpose. The main purpose is to define more accurately the epileptogenic zone (EZ) with noninvasive methods in those patients with MRI diagnosis of focal cortical dysplasia (FCD) and epilepsy who are candidates of epilepsy surgery. Methods. Twenty patients were evaluated prospectively between 2007 and 2010 with comprehensive clinical evaluation, video-electroencephalography, diffusion tensor imaging (DTI), and high-resolution EEG to localize the equivalent current dipole (ECD). Key Findings. In 11 cases with white matter asymmetries in DTI the ECDs were located next to lesion on MRI with mean distance of 14.63 millimeters with topographical correlation with the EZ. Significance. We could establish a hypothesis of EZ based on Video-EEG, high-resolution EEG, ECD method, MRI, and DTI. These results are consistent with the hypothesis that the EZ in the FCD is complex and is often larger than visible lesion in MRI.

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