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Alzamendi A, Del Zotto H, Castrogiovanni D, et al. Oral metformin treatment prevents enhanced insulin demand and placental dysfunction in the pregnant rat fed a fructose-rich diet. ISRN Endocrinol. 2012;2012:757913doi: 10.5402/2012/757913.
Alzamendi, A., Del Zotto, H., Castrogiovanni, D., Romero, J., Giovambattista, A., & Spinedi, E. (2012). Oral metformin treatment prevents enhanced insulin demand and placental dysfunction in the pregnant rat fed a fructose-rich diet. ISRN endocrinology, 2012757913. https://doi.org/10.5402/2012/757913
Alzamendi, Ana, et al. "Oral metformin treatment prevents enhanced insulin demand and placental dysfunction in the pregnant rat fed a fructose-rich diet." ISRN endocrinology vol. 2012 (2012): 757913. doi: https://doi.org/10.5402/2012/757913
Alzamendi A, Del Zotto H, Castrogiovanni D, Romero J, Giovambattista A, Spinedi E. Oral metformin treatment prevents enhanced insulin demand and placental dysfunction in the pregnant rat fed a fructose-rich diet. ISRN Endocrinol. 2012;2012:757913. doi: 10.5402/2012/757913. Epub 2012 Aug 16. PMID: 22957268; PMCID: PMC3431097.
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ISRN Endocrinol. 2012;2012:757913. doi: 10.5402/2012/757913. Epub 2012 Aug 16.

Oral metformin treatment prevents enhanced insulin demand and placental dysfunction in the pregnant rat fed a fructose-rich diet.

ISRN endocrinology

Ana Alzamendi, Hector Del Zotto, Daniel Castrogiovanni, Jose Romero, Andres Giovambattista, Eduardo Spinedi

Affiliations

  1. Neuroendocrine Unit, IMBICE (CONICET La Plata-CICPBA), P.O. Box 403, 1900 La Plata, Argentina.

PMID: 22957268 PMCID: PMC3431097 DOI: 10.5402/2012/757913

Abstract

The intake of a fructose-rich diet (FRD) in the normal female rat induces features similar to those observed in the human metabolic syndrome phenotype. We studied the impact of FRD administration to mothers on pregnancy outcome. On gestational day (Gd) zero rats were assigned to either group: ad libitum drinking tap water alone (normal diet, ND) or containing fructose (10% w/vol; FRD) through pregnancy; all rats were fed a Purina chow diet ad libitum ND and FRD rats were daily cotreated or not with metformin (60 mg/Kg/day oral; ND + MF and FRD + MF) and submitted to a high glucose load test on Gd 14. Additionally, placentas from different groups were studied on Gd 20. Data indicated that: (1) although FRD rats well tolerated glucose overload, their circulating levels of insulin were significantly higher than in ND rats; (2) the mesometrial triangle blood vessel area was significantly lower in placentas from FRD than ND dams; (3) the detrimental effects of FRD administration to mothers were ameliorated by metformin cotreatment. Our study suggests that excessive intake of fructose during pregnancy enhanced the risk for developing gestational diabetes and subsequent preeclampsia, and that metformin prevented the poor pregnancy outcome induced by FRD.

References

  1. Obesity (Silver Spring). 2010 Feb;18(2):340-6 - PubMed
  2. Endocrine. 2009 Apr;35(2):227-32 - PubMed
  3. J Nutr. 2003 May;133(5 Suppl 2):1674S-1683S - PubMed
  4. J Soc Gynecol Investig. 2005 Apr;12(3):174-84 - PubMed
  5. Endocrinology. 2010 Sep;151(9):4214-23 - PubMed
  6. Circulation. 2002 Jan 22;105(3):373-9 - PubMed
  7. Placenta. 2005 May;26(5):410-8 - PubMed
  8. Exp Physiol. 2007 Mar;92(2):287-98 - PubMed
  9. Diabet Med. 2011 Sep;28(9):1074-7 - PubMed
  10. Diabetes Care. 2001 Jul;24(7):1151-5 - PubMed
  11. Am J Clin Nutr. 2004 Apr;79(4):537-43 - PubMed
  12. J Nutr. 1993 Dec;123(12):2158-65 - PubMed
  13. Obesity (Silver Spring). 2010 Mar;18(3):441-8 - PubMed
  14. Physiol Rev. 2005 Apr;85(2):571-633 - PubMed
  15. Ther Drug Monit. 2006 Feb;28(1):67-72 - PubMed
  16. J Clin Endocrinol Metab. 2002 Apr;87(4):1563-8 - PubMed
  17. J Nutr. 1992 Feb;122(2):385-92 - PubMed
  18. Curr Vasc Pharmacol. 2009 Oct;7(4):460-6 - PubMed
  19. Hypertension. 2004 May;43(5):988-92 - PubMed
  20. Am J Obstet Gynecol. 2010 Apr;202(4):368.e1-8 - PubMed
  21. Eur J Obstet Gynecol Reprod Biol. 2008 Apr;137(2):178-84 - PubMed
  22. Diabetes Care. 1993 Jan;16(1):310-4 - PubMed
  23. Cell Biochem Biophys. 2007;48(2-3):79-88 - PubMed
  24. J Clin Invest. 2003 May;111(9):1373-80 - PubMed
  25. Nephrol Dial Transplant. 2006 Nov;21(11):3052-4 - PubMed
  26. Horm Metab Res. 2008 Nov;40(11):794-800 - PubMed
  27. J Nutr. 2010 Mar;140(3):658-61 - PubMed
  28. Obstet Gynecol. 2012 Mar;119(3):560-5 - PubMed
  29. J Perinat Med. 2012 Jan 10;40(3):225-8 - PubMed
  30. Mol Endocrinol. 2002 Aug;16(8):1931-42 - PubMed
  31. J Cell Biol. 2008 Jun 2;181(5):847-58 - PubMed
  32. Diabetes Care. 1999 Aug;22(8):1284-91 - PubMed
  33. Am J Obstet Gynecol. 2004 Mar;190(3):858-65 - PubMed
  34. Obstet Gynecol. 1994 Mar;83(3):462-5 - PubMed
  35. Eur J Obstet Gynecol Reprod Biol. 2012 Feb;160(2):147-50 - PubMed
  36. Acta Obstet Gynecol Scand. 2010 Nov;89(11):1478-85 - PubMed
  37. Am J Clin Nutr. 2002 Nov;76(5):911-22 - PubMed
  38. Diabetes Care. 1998 Aug;21 Suppl 2:B142-9 - PubMed

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