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Novaretti MC, Dinardo CL. Clinical applications of immunoglobulin: update. Rev Bras Hematol Hemoter. 2011;33(3):221-30doi: 10.5581/1516-8484.20110058.
Novaretti, M. C., & Dinardo, C. L. (2011). Clinical applications of immunoglobulin: update. Revista brasileira de hematologia e hemoterapia, 33(3), 221-30. https://doi.org/10.5581/1516-8484.20110058
Novaretti, Marcia Cristina Zago, and Dinardo, Carla Luana. "Clinical applications of immunoglobulin: update." Revista brasileira de hematologia e hemoterapia vol. 33,3 (2011): 221-30. doi: https://doi.org/10.5581/1516-8484.20110058
Novaretti MC, Dinardo CL. Clinical applications of immunoglobulin: update. Rev Bras Hematol Hemoter. 2011;33(3):221-30. doi: 10.5581/1516-8484.20110058. PMID: 23049300; PMCID: PMC3415732.
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Rev Bras Hematol Hemoter. 2011;33(3):221-30. doi: 10.5581/1516-8484.20110058.

Clinical applications of immunoglobulin: update.

Revista brasileira de hematologia e hemoterapia

Marcia Cristina Zago Novaretti, Carla Luana Dinardo

Affiliations

  1. Blood Transfusion Service, Instituto do Câncer do Estado de São Paulo - ICESP, São Paulo, SP, Brazil.

PMID: 23049300 PMCID: PMC3415732 DOI: 10.5581/1516-8484.20110058

Abstract

Human immunoglobulin is the most used blood product in the clinical practice. Immunoglobulin applications have increased quickly since the elucidation of its immunomodulatory and antiinflammatory properties which turned this blood product into a precious tool in the treatment of numerous diseases that present with humoral immune deficiency or that cause immune system dysfunction. Currently, the approved indications for Ig are: primary immunodeficiencies, secondary immunodeficiencies (multiple myeloma or chronic lymphoid leukemia), Kawasaki syndrome, immune thrombocytopenic purpura, Guillain Barré syndrome, graft-versus-host disease following bone marrow transplantation and repeat infections in HIV children. On the other hand, there are numerous "off-label" indications of immunoglobulin, which represent 20-60% of all clinical applications of this drug. It is important to study all these indications and, above all, the scientific evidence for its use, in order to provide patients with a new therapeutic option without burdening the health system. This review results from a wide selection of papers identified in the Pubmed and Lilacs scientific electronic databases. A group of descriptors were used from human immunoglobulin to the names of each disease that immunoglobulin is clinically applied. Our main objective is to list the numerous indications of immunoglobulin, both authorized and "off-label" and to analyze these indications in the light of the most recent scientific evidence.

Keywords: Guillain-Barre syndrome; Immune system diseases; Immunoglobulin, intravenous; Plasma; Purpura, thrombocytopenic, idiopathic

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