Display options
Cite
Stravodimou A, Mazzoccoli G, Voutsadakis IA. Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer. PPAR Res. 2012;2012:367450doi: 10.1155/2012/367450.
Stravodimou, A., Mazzoccoli, G., & Voutsadakis, I. A. (2012). Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer. PPAR research, 2012367450. https://doi.org/10.1155/2012/367450
Stravodimou, Athina, et al. "Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer." PPAR research vol. 2012 (2012): 367450. doi: https://doi.org/10.1155/2012/367450
Stravodimou A, Mazzoccoli G, Voutsadakis IA. Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer. PPAR Res. 2012;2012:367450. doi: 10.1155/2012/367450. Epub 2012 Sep 19. PMID: 23049538; PMCID: PMC3459232.
Copy Download .nbib Format: NLM
Share it on

PPAR Res. 2012;2012:367450. doi: 10.1155/2012/367450. Epub 2012 Sep 19.

Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer.

PPAR research

Athina Stravodimou, Gianluigi Mazzoccoli, Ioannis A Voutsadakis

Affiliations

  1. Centre Pluridisciplinaire d'Oncologie, Centre Hospitalier Universitaire Vaudois, BH06, Bugnon 46, 1011 Lausanne, Switzerland.

PMID: 23049538 PMCID: PMC3459232 DOI: 10.1155/2012/367450

Abstract

Pancreatic cancer is one of the most lethal forms of human cancer. Although progress in oncology has improved outcomes in many forms of cancer, little progress has been made in pancreatic carcinoma and the prognosis of this malignancy remains grim. Several molecular abnormalities often present in pancreatic cancer have been defined and include mutations in K-ras, p53, p16, and DPC4 genes. Nuclear receptor Peroxisome Proliferator-Activated Receptor gamma (PPARγ) has a role in many carcinomas and has been found to be overexpressed in pancreatic cancer. It plays generally a tumor suppressor role antagonizing proteins promoting carcinogenesis such as NF-κB and TGFβ. Regulation of pathways involved in pancreatic carcinogenesis is effectuated by the Ubiquitin Proteasome System (UPS). This paper will examine PPARγ in pancreatic cancer, the regulation of this nuclear receptor by the UPS, and their relationship to other pathways important in pancreatic carcinogenesis.

References

  1. Nature. 2005 Sep 29;437(7059):759-63 - PubMed
  2. Am J Pathol. 2006 Oct;169(4):1303-11 - PubMed
  3. Pancreas. 2004 Mar;28(2):153-9 - PubMed
  4. J Biomed Sci. 2012 Jul 24;19:67 - PubMed
  5. J Cell Sci. 2012 Feb 1;125(Pt 3):539-48 - PubMed
  6. FASEB J. 2010 Apr;24(4):981-93 - PubMed
  7. Cell. 2008 May 16;133(4):704-15 - PubMed
  8. Cell. 2004 Feb 20;116(4):511-26 - PubMed
  9. Cancer Discov. 2011 Jul;1(2):158-69 - PubMed
  10. Biochim Biophys Acta. 2011 Apr;1815(2):135-46 - PubMed
  11. Drug Saf. 2001;24(12):873-88 - PubMed
  12. J Cell Sci. 2012 Feb 1;125(Pt 3):549-59 - PubMed
  13. Int J Cell Biol. 2011;2011:816791 - PubMed
  14. J Clin Invest. 2009 Jun;119(6):1420-8 - PubMed
  15. Nat Struct Mol Biol. 2011 May;18(5):520-8 - PubMed
  16. Biochem Biophys Res Commun. 2012 May 4;421(2):349-54 - PubMed
  17. HPB (Oxford). 2009 Nov;11(7):600-5 - PubMed
  18. PPAR Res. 2010;2010: - PubMed
  19. Mol Cell Biochem. 2007 Oct;304(1-2):71-7 - PubMed
  20. Biochem J. 2012 Jan 15;441(2):541-52 - PubMed
  21. J Biol Chem. 2006 Aug 25;281(34):24575-87 - PubMed
  22. BMC Biol. 2012 Mar 15;10:25 - PubMed
  23. J Pathol. 2011 Dec;225(4):475-8 - PubMed
  24. J Biol Chem. 1997 Apr 18;272(16):10811-6 - PubMed
  25. Cell Biosci. 2012 Mar 15;2:9 - PubMed
  26. BMJ. 2012 May 30;344:e3645 - PubMed
  27. N Engl J Med. 2011 May 12;364(19):1817-25 - PubMed
  28. Nature. 2009 Mar 26;458(7237):461-7 - PubMed
  29. J Cell Sci. 2012 Jan 15;125(Pt 2):249-54 - PubMed
  30. J Hypertens. 2011 Sep;29(9):1810-9 - PubMed
  31. J Histochem Cytochem. 2000 May;48(5):603-11 - PubMed
  32. J Biol Chem. 2000 Jun 16;275(24):18527-33 - PubMed
  33. Curr Biol. 2001 May 15;11(10):764-8 - PubMed
  34. J Cell Sci. 2012 Jan 15;125(Pt 2):265-75 - PubMed
  35. J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:69-74 - PubMed
  36. Cancer Sci. 2008 Nov;99(11):2107-12 - PubMed
  37. Cancer Sci. 2008 Oct;99(10):1892-900 - PubMed
  38. Cell Mol Life Sci. 2008 Aug;65(15):2397-406 - PubMed
  39. PLoS One. 2011;6(6):e20537 - PubMed
  40. Mol Cancer Ther. 2010 Dec;9(12):3221-32 - PubMed
  41. J Biol Chem. 2003 Aug 29;278(35):33571-82 - PubMed
  42. World J Gastroenterol. 2009 Jan 28;15(4):441-8 - PubMed
  43. Gastrointest Cancer Res. 2007;1(4 Suppl 2):S7-S12 - PubMed
  44. N Engl J Med. 2004 Sep 9;351(11):1106-18 - PubMed
  45. PLoS One. 2011 Jan 06;6(1):e15909 - PubMed
  46. PPAR Res. 2010;2010: - PubMed
  47. J Biol Chem. 1997 Jul 25;272(30):18779-89 - PubMed
  48. Nat Rev Mol Cell Biol. 2009 May;10(5):319-31 - PubMed
  49. Nature. 1998 Jan 1;391(6662):79-82 - PubMed
  50. J Biol Chem. 2009 Sep 18;284(38):26184-93 - PubMed
  51. Cell Biosci. 2011 Dec 28;1:42 - PubMed
  52. Tumour Biol. 2012 Aug;33(4):897-910 - PubMed
  53. J Cancer Res Clin Oncol. 2007 Dec;133(12):917-28 - PubMed
  54. Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):380-4 - PubMed
  55. Int J Oncol. 2012 Mar;40(3):679-85 - PubMed
  56. Exp Cell Res. 2003 Sep 10;289(1):143-51 - PubMed
  57. Biochimie. 2005 Jan;87(1):33-8 - PubMed
  58. Small GTPases. 2010 Jul;1(1):2-27 - PubMed
  59. J Cell Sci. 2012 Jan 15;125(Pt 2):255-63 - PubMed
  60. Clin Cancer Res. 2006 Nov 1;12(21):6444-51 - PubMed
  61. Nature. 1998 Jan 1;391(6662):82-6 - PubMed
  62. J Cell Mol Med. 2007 Mar-Apr;11(2):252-85 - PubMed
  63. Mol Cell Biol. 2003 Jul;23(13):4542-58 - PubMed
  64. Cell. 2008 Jul 25;134(2):215-30 - PubMed
  65. Expert Opin Ther Targets. 2011 Mar;15(3):253-64 - PubMed
  66. World J Gastroenterol. 2005 Feb 28;11(8):1122-30 - PubMed
  67. Cell Biosci. 2011 Dec 28;1(1):43 - PubMed
  68. Gastroenterology. 2005 Apr;128(4):907-21 - PubMed
  69. Mol Cell. 2002 May;9(5):945-56 - PubMed
  70. Nat Immunol. 2011 Jul 19;12(8):715-23 - PubMed
  71. J Cell Sci. 2012 Feb 1;125(Pt 3):531-7 - PubMed
  72. Am J Physiol Gastrointest Liver Physiol. 2002 Aug;283(2):G266-9 - PubMed
  73. J Clin Invest. 2011 Dec;121(12):4685-99 - PubMed
  74. Cell. 2007 Jun 15;129(6):1125-40 - PubMed
  75. Trends Biochem Sci. 2012 Jan;37(1):23-31 - PubMed
  76. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20603-8 - PubMed
  77. Mol Cell Biol. 2012 Jan;32(2):266-75 - PubMed
  78. Mol Endocrinol. 2011 Mar;25(3):394-408 - PubMed
  79. FEBS Lett. 2003 Nov 6;554(1-2):77-80 - PubMed
  80. Chem Biol. 2001 Dec;8(12):1131-41 - PubMed
  81. Mol Cell. 2010 Jun 11;38(5):627-35 - PubMed
  82. Oncogene. 2003 Jul 3;22(27):4186-93 - PubMed
  83. Nucl Recept Signal. 2012;10:e001 - PubMed
  84. Gut. 2004 Nov;53(11):1688-97 - PubMed
  85. Biochem Biophys Res Commun. 2002 Jun 28;294(5):976-80 - PubMed
  86. Cell Cycle. 2011 Jul 15;10(14):2344-54 - PubMed
  87. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):397-405 - PubMed
  88. Semin Cancer Biol. 2010 Feb;20(1):10-8 - PubMed
  89. BMC Biol. 2012 Mar 15;10:23 - PubMed
  90. Life Sci. 2002 Feb 15;70(13):1565-75 - PubMed
  91. J Cell Sci. 2012 Jan 15;125(Pt 2):277-86 - PubMed
  92. J Clin Oncol. 1997 Jun;15(6):2403-13 - PubMed
  93. Carcinogenesis. 2007 Aug;28(8):1692-6 - PubMed
  94. Ann Oncol. 2005 Oct;16(10):1654-61 - PubMed
  95. Int J Biochem Cell Biol. 2008;40(4):677-88 - PubMed
  96. Steroids. 2010 Aug-Sep;75(8-9):585-94 - PubMed
  97. Mol Cell Biol. 2007 Feb;27(3):803-17 - PubMed
  98. N Engl J Med. 2010 Apr 29;362(17):1605-17 - PubMed
  99. Urol Oncol. 2012 Nov-Dec;30(6):752-61 - PubMed
  100. Biochem Biophys Res Commun. 2003 Jan 31;301(1):50-3 - PubMed
  101. Expert Opin Investig Drugs. 2006 Sep;15(9):1039-49 - PubMed
  102. Diabetes. 1998 Mar;47(3):490-2 - PubMed
  103. Cancer Cell. 2007 May;11(5):395-406 - PubMed
  104. Trends Pharmacol Sci. 2011 Mar;32(3):131-40 - PubMed
  105. Mol Cell Biol. 2010 May;30(9):2135-46 - PubMed
  106. J Gastroenterol. 2004;39(5):461-8 - PubMed
  107. World J Gastrointest Oncol. 2011 Nov 15;3(11):153-64 - PubMed
  108. Br J Haematol. 2010 Oct;151(1):3-15 - PubMed
  109. Hepatology. 2003 Jul;38(1):167-77 - PubMed
  110. Nature. 1998 Nov 26;396(6709):377-80 - PubMed
  111. Mol Pharmacol. 2006 Jul;70(1):415-25 - PubMed
  112. Biochemistry. 2011 Jun 28;50(25):5566-82 - PubMed
  113. Oncogene. 2004 Nov 11;23(53):8571-80 - PubMed
  114. EMBO Mol Med. 2009 Sep;1(6-7):303-14 - PubMed
  115. Biochim Biophys Acta. 2004 Nov 29;1695(1-3):19-31 - PubMed
  116. Mol Cancer Res. 2006 Mar;4(3):159-67 - PubMed
  117. J Clin Invest. 2010 May;120(5):1454-68 - PubMed
  118. Pancreas. 2002 Jan;24(1):1-7 - PubMed
  119. Oncogene. 2009 Dec 10;28(49):4317-25 - PubMed
  120. Mol Endocrinol. 2004 Mar;18(3):493-9 - PubMed
  121. Clin Cancer Res. 2009 Jul 15;15(14):4674-9 - PubMed

Publication Types