Antimicrob Resist Infect Control. 2012 May 29;1(1):19. doi: 10.1186/2047-2994-1-19.
Daptomycin exposure precedes infection and/or colonization with daptomycin non-susceptible enterococcus.
Antimicrobial resistance and infection control
Jeremy C Storm, Daniel J Diekema, Jennifer S Kroeger, Sarah J Johnson, Birgir Johannsson
PMID: 22958379
PMCID: PMC3436660 DOI: 10.1186/2047-2994-1-19
Abstract
BACKGROUND: Daptomycin non-susceptible enterococci (DNSE) are emerging as an important cause of healthcare-associated infection, however little is known about the epidemiology of DNSE. At the University of Iowa Hospitals and Clinics (UIHC) an increase in the frequency of patients infected and/or colonized with DNSE has occurred. The goals of this study were to evaluate potential factors associated with the development of DNSE colonization and/or infection and to compare the characteristics of patients with prior daptomycin exposure to those without prior daptomycin exposure.
METHODS: The study is a retrospective case-series involving all patients with DNSE infection and/or colonization at UIHC, a 734-bed academic referral center, from June 1, 2005 to June 1, 2011.
RESULTS: The majority of patients with DNSE colonization and/or infection had prior daptomycin exposure (15 of 25; 60%), a concomitant gastrointestinal process (19 of 25; 76%), or were immunosuppressed (21 of 25; 84%). DNSE infection was confirmed in 17 of 25 (68%) patients, including 9 patients with bacteremia. Twelve of 17 (71%) patients with DNSE infection had prior daptomycin exposure, including 7 of 9 (78%) patients with bacteremia. Compared to patients without prior daptomycin exposure, patients with prior daptomycin exposure were less likely to harbor E. faecalis (0% vs. 33%; pā=ā0.019). A high proportion of patients (10 of 25; 40%) died during their hospitalizations. Most enterococcal isolates were E. faecium (86%), and were vancomycin-resistant (72%). Molecular typing revealed a diverse population of DNSE.
CONCLUSIONS: Prior daptomycin exposure, immunosuppression, and/or a concomitant gastrointestinal process, may be associated with the development of DNSE. PFGE revealed a diverse population of DNSE, which along with both increasing numbers of DNSE detected yearly and increasing annual rates of daptomycin usage, suggests the emergence of DNSE under antimicrobial pressure.
References
- Clin Infect Dis. 2001 Jul 15;33(2):210-9 - PubMed
- Arch Intern Med. 2002 Oct 28;162(19):2223-8 - PubMed
- N Engl J Med. 2011 Sep 8;365(10):892-900 - PubMed
- J Infect. 1996 Jan;32(1):11-6 - PubMed
- Semin Respir Crit Care Med. 2007 Dec;28(6):632-45 - PubMed
- Diagn Microbiol Infect Dis. 2011 Jul;70(3):412-6 - PubMed
- Antimicrob Agents Chemother. 2011 Jul;55(7):3345-56 - PubMed
- J Clin Microbiol. 1995 Sep;33(9):2233-9 - PubMed
- Clin Infect Dis. 2011 Jan 15;52(2):228-34 - PubMed
- Am J Infect Control. 2004 Dec;32(8):470-85 - PubMed
- J Hosp Infect. 2007 Apr;65(4):376-8 - PubMed
- MMWR Morb Mortal Wkly Rep. 2002 Jul 5;51(26):565-7 - PubMed
- Antimicrob Agents Chemother. 2008 Jan;52(1):269-78 - PubMed
- J Clin Microbiol. 2006 Feb;44(2):673 - PubMed
- Antimicrob Agents Chemother. 2012 Apr;56(4):2150-2 - PubMed
- Antimicrob Agents Chemother. 2009 Jun;53(6):2312-8 - PubMed
- Clin Infect Dis. 2004 Aug 1;39(3):309-17 - PubMed
- Emerg Infect Dis. 2012 Apr;18(4):674-6 - PubMed
- Diagn Microbiol Infect Dis. 2009 Oct;65(2):158-62 - PubMed
- Infect Control Hosp Epidemiol. 2011 Apr;32(4):391-4 - PubMed
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