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Cascio CJ, Foss-Feig JH, Heacock JL, et al. Response of neural reward regions to food cues in autism spectrum disorders. J Neurodev Disord. 2012;4(1):9doi: 10.1186/1866-1955-4-9.
Cascio, C. J., Foss-Feig, J. H., Heacock, J. L., Newsom, C. R., Cowan, R. L., Benningfield, M. M., Rogers, B. P., & Cao, A. (2012). Response of neural reward regions to food cues in autism spectrum disorders. Journal of neurodevelopmental disorders, 4(1), 9. https://doi.org/10.1186/1866-1955-4-9
Cascio, Carissa J, et al. "Response of neural reward regions to food cues in autism spectrum disorders." Journal of neurodevelopmental disorders vol. 4,1 (2012): 9. doi: https://doi.org/10.1186/1866-1955-4-9
Cascio CJ, Foss-Feig JH, Heacock JL, Newsom CR, Cowan RL, Benningfield MM, Rogers BP, Cao A. Response of neural reward regions to food cues in autism spectrum disorders. J Neurodev Disord. 2012 May 17;4(1):9. doi: 10.1186/1866-1955-4-9. PMID: 22958533; PMCID: PMC3436657.
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J Neurodev Disord. 2012 May 17;4(1):9. doi: 10.1186/1866-1955-4-9.

Response of neural reward regions to food cues in autism spectrum disorders.

Journal of neurodevelopmental disorders

Carissa J Cascio, Jennifer H Foss-Feig, Jessica L Heacock, Cassandra R Newsom, Ronald L Cowan, Margaret M Benningfield, Baxter P Rogers, Aize Cao

Affiliations

  1. Department of Psychiatry, Vanderbilt University, 1601 23rd Ave South, Suite 3057, Nashville, TN 37212, USA. [email protected].

PMID: 22958533 PMCID: PMC3436657 DOI: 10.1186/1866-1955-4-9

Abstract

BACKGROUND: One hypothesis for the social deficits that characterize autism spectrum disorders (ASD) is diminished neural reward response to social interaction and attachment. Prior research using established monetary reward paradigms as a test of non-social reward to compare with social reward may involve confounds in the ability of individuals with ASD to utilize symbolic representation of money and the abstraction required to interpret monetary gains. Thus, a useful addition to our understanding of neural reward circuitry in ASD includes a characterization of the neural response to primary rewards.

METHOD: We asked 17 children with ASD and 18 children without ASD to abstain from eating for at least four hours before an MRI scan in which they viewed images of high-calorie foods. We assessed the neural reward network for increases in the blood oxygenation level dependent (BOLD) signal in response to the food images

RESULTS: We found very similar patterns of increased BOLD signal to these images in the two groups; both groups showed increased BOLD signal in the bilateral amygdala, as well as in the nucleus accumbens, orbitofrontal cortex, and insula. Direct group comparisons revealed that the ASD group showed a stronger response to food cues in bilateral insula along the anterior-posterior gradient and in the anterior cingulate cortex than the control group, whereas there were no neural reward regions that showed higher activation for controls than for ASD.

CONCLUSION: These results suggest that neural response to primary rewards is not diminished but in fact shows an aberrant enhancement in children with ASD.

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