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Steinert T, Hamann K. External validity of studies on aggressive behavior in patients with schizophrenia: systematic review. Clin Pract Epidemiol Ment Health. 2012;8:74-80doi: 10.2174/1745017901208010074.
Steinert, T., & Hamann, K. (2012). External validity of studies on aggressive behavior in patients with schizophrenia: systematic review. Clinical practice and epidemiology in mental health : CP & EMH, 874-80. https://doi.org/10.2174/1745017901208010074
Steinert, Tilman, and Hamann, Karen. "External validity of studies on aggressive behavior in patients with schizophrenia: systematic review." Clinical practice and epidemiology in mental health : CP & EMH vol. 8 (2012): 74-80. doi: https://doi.org/10.2174/1745017901208010074
Steinert T, Hamann K. External validity of studies on aggressive behavior in patients with schizophrenia: systematic review. Clin Pract Epidemiol Ment Health. 2012;8:74-80. doi: 10.2174/1745017901208010074. Epub 2012 Aug 23. PMID: 22934120; PMCID: PMC3428629.
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Clin Pract Epidemiol Ment Health. 2012;8:74-80. doi: 10.2174/1745017901208010074. Epub 2012 Aug 23.

External validity of studies on aggressive behavior in patients with schizophrenia: systematic review.

Clinical practice and epidemiology in mental health : CP & EMH

Tilman Steinert, Karen Hamann

Affiliations

  1. Centre for Psychiatry Suedwuerttemberg, Ulm University, Germany.

PMID: 22934120 PMCID: PMC3428629 DOI: 10.2174/1745017901208010074

Abstract

STUDIES ON VIOLENCE IN SCHIZOPHRENIA USE TWO DIFFERENT APPROACHES: use of epidemiological data, and clinical studies recording direct patient data after gaining informed consent. With regard to informed consent requiring agreement and cooperation, the question arises as to what extent participants represent patients with schizophrenia and violent behaviour (external validity). We conducted a systematic literature research. In most of the studies, aggression or violence, respectively, were poorly defined. Only 5 (15.2%) studies used a cut-off score on an aggression scale. Only 6 studies (18.2%) reported the number of patients who refused to participate, and 16 (48.5%) reported the number of drop-outs. Only 3 studies (9.1%) reported a systematic comparison of participants and non-participants. We found that data which allow for the assessment of representativeness of the investigated samples are poorly reported. For most studies, doubts regarding external validity seem justified and generalisability is questionable due to possible selection bias.

Keywords: Aggression; external validity; review; schizophrenia; violence.

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