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Hanif M, Shoaib K, Saleem M, et al. Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives. ISRN Pharmacol. 2012;2012:928901doi: 10.5402/2012/928901.
Hanif, M., Shoaib, K., Saleem, M., Hasan Rama, N., Zaib, S., & Iqbal, J. (2012). Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives. ISRN pharmacology, 2012928901. https://doi.org/10.5402/2012/928901
Hanif, Muhammad, et al. "Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives." ISRN pharmacology vol. 2012 (2012): 928901. doi: https://doi.org/10.5402/2012/928901
Hanif M, Shoaib K, Saleem M, Hasan Rama N, Zaib S, Iqbal J. Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives. ISRN Pharmacol. 2012;2012:928901. doi: 10.5402/2012/928901. Epub 2012 Aug 13. PMID: 22934191; PMCID: PMC3425833.
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ISRN Pharmacol. 2012;2012:928901. doi: 10.5402/2012/928901. Epub 2012 Aug 13.

Synthesis, urease inhibition, antioxidant, antibacterial, and molecular docking studies of 1,3,4-oxadiazole derivatives.

ISRN pharmacology

Muhammad Hanif, Khurram Shoaib, Muhammad Saleem, Nasim Hasan Rama, Sumera Zaib, Jamshed Iqbal

Affiliations

  1. Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.

PMID: 22934191 PMCID: PMC3425833 DOI: 10.5402/2012/928901

Abstract

A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of Jack bean urease. The molecular docking studies were performed by docking them into the crystal structure of Jack bean urease to observe the mode of interaction of synthesized compounds. The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results.

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