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Howard-Thompson A, Christensen ML. Elevated tobramycin concentrations following endotracheal administration in a premature infant. J Pediatr Pharmacol Ther. 2008;13(2):88-92doi: 10.5863/1551-6776-13.2.88.
Howard-Thompson, A., & Christensen, M. L. (2008). Elevated tobramycin concentrations following endotracheal administration in a premature infant. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 13(2), 88-92. https://doi.org/10.5863/1551-6776-13.2.88
Howard-Thompson, Amanda, and Christensen, Michael L. "Elevated tobramycin concentrations following endotracheal administration in a premature infant." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 13,2 (2008): 88-92. doi: https://doi.org/10.5863/1551-6776-13.2.88
Howard-Thompson A, Christensen ML. Elevated tobramycin concentrations following endotracheal administration in a premature infant. J Pediatr Pharmacol Ther. 2008 Apr;13(2):88-92. doi: 10.5863/1551-6776-13.2.88. PMID: 23055870; PMCID: PMC3462063.
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J Pediatr Pharmacol Ther. 2008 Apr;13(2):88-92. doi: 10.5863/1551-6776-13.2.88.

Elevated tobramycin concentrations following endotracheal administration in a premature infant.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Amanda Howard-Thompson, Michael L Christensen

Affiliations

  1. Department of Clinical Pharmacy and the Center for Pediatric Pharmacokinetics and Therapeutics, University of Tennessee Health Science Center and LeBonheur Children's Medical Center, Memphis, Tennessee.

PMID: 23055870 PMCID: PMC3462063 DOI: 10.5863/1551-6776-13.2.88

Abstract

The following case report describes a 1-month-old, 34-week-gestation premature neonate who had compromised renal function. The neonate received endotracheally administered tobramycin (300 mg every 12 hours) via a PARI PLUS reusable nebulizer to treat a documented Gram-negative tracheostomy infection. The patient also received systemic tobramycin (2.5 mg/kg intravenously every 18 hours). The tobramycin serum concentration obtained 45 hours after the last intravenous dose and 11.5 hours after the second nebulized dose was 17.6 mg/L. The tobramycin nebulizations were stopped.

Keywords: endotracheal; neonate; tobramycin

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