Display options
Cite
Kiew KK, Wan Mohamad WB, Ridzuan A, et al. Effects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabetics. Malays J Med Sci. 2002;9(1):21-7
Kiew, K. K., Wan Mohamad, W. B., Ridzuan, A., & Mafauzy, M. (2002). Effects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabetics. The Malaysian journal of medical sciences : MJMS, 9(1), 21-7.
Kiew, K K, et al. "Effects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabetics." The Malaysian journal of medical sciences : MJMS vol. 9,1 (2002): 21-7.
Kiew KK, Wan Mohamad WB, Ridzuan A, Mafauzy M. Effects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabetics. Malays J Med Sci. 2002 Jan;9(1):21-7. PMID: 22969314; PMCID: PMC3436103.
Copy Download .nbib Format: NLM
Share it on

Malays J Med Sci. 2002 Jan;9(1):21-7.

Effects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabetics.

The Malaysian journal of medical sciences : MJMS

K K Kiew, W B Wan Mohamad, A Ridzuan, M Mafauzy

Affiliations

  1. Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

PMID: 22969314 PMCID: PMC3436103

Abstract

Thirty patients with diabetic polyneuropathy were recruited from the diabetic clinic in Hospital Universiti Sains Malaysia from 1996 to 1998. They were randomly assigned either sulbutiamine (Arcalion(®)) (15 patients) or no treatment (control group; 15 patients). Glycaemic control was assessed by blood glucose and HbA1. Severity of neuropathy was assessed by symptom and sign score, and electrophysiological parameters (nerve conduction velocity and compound muscle action potential) at entry to the study and after 6 weeks. There were improvements in the electrophysiological parameters in the treatment group when compared to the controls with significant improvement in the median nerve conduction velocity (p<0.001), median compound muscle action potential (p<0.001), peroneal nerve conduction velocity (p<0.001), and peroneal compound muscle action potential (p<0.001). No significant improvement in symptom and sign scores were noted between the groups but a significant improvement compared to base line was noted for the sulbutiamine treated group. (p< 0.05). The glycaemic control in both groups was not significantly different at base line and was stable throughout the study. Sulbutiamine objectively improved peripheral nerve function in diabetic polyneuropathy although the symptom score did not improve, possibly due to the short duration of the study.

Keywords: CMAP; NCV; diabetic polyneuropathy; sulbutiamine

References

  1. Drugs Aging. 1995 Jan;6(1):9-28 - PubMed
  2. Ann Neurol. 1986 May;19(5):440-9 - PubMed
  3. Ann Neurol. 1986 May;19(5):425-39 - PubMed
  4. J Diabetes Complications. 1995 Jan-Mar;9(1):25-30 - PubMed
  5. Folia Med (Plovdiv). 1997;39(4):5-10 - PubMed
  6. J Nutr Sci Vitaminol (Tokyo). 1987 Dec;33(6):421-30 - PubMed
  7. Diabetologia. 1985 Oct;28(10):722-7 - PubMed
  8. Biochem Pharmacol. 1990 Dec 1;40(11):2557-60 - PubMed
  9. Drugs Aging. 1993 Nov-Dec;3(6):532-55 - PubMed
  10. Ann Intern Med. 1996 Jan 1;124(1 Pt 2):90-6 - PubMed
  11. Prostaglandins. 1991 Jan;41(1):85-96 - PubMed
  12. J Diabetes Complications. 1998 May-Jun;12(3):121-7 - PubMed
  13. Diabetes. 1988 Apr;37(4):476-81 - PubMed
  14. Lancet. 1998 Sep 12;352(9131):837-53 - PubMed
  15. Diabet Med. 1996 Dec;13(12):1017-26 - PubMed
  16. Diabetes. 1983 Jul;32(7):654-63 - PubMed
  17. Pharmacol Biochem Behav. 1985 Aug;23(2):195-8 - PubMed
  18. Biochem Biophys Res Commun. 1988 Jan 15;150(1):225-30 - PubMed
  19. Rev Electroencephalogr Neurophysiol Clin. 1982 Dec;12(4):373-8 - PubMed
  20. Ann Acad Med Singap. 1980 Jan;9(1):65-70 - PubMed
  21. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6 - PubMed
  22. J Clin Invest. 1990 May;85(5):1410-20 - PubMed
  23. Prostaglandins. 1990 Nov;40(5):463-71 - PubMed
  24. J Nutr Sci Vitaminol (Tokyo). 1989 Feb;35(1):95-9 - PubMed
  25. East Afr Med J. 1997 Dec;74(12):803-8 - PubMed
  26. Ann Intern Med. 1993 Jan 1;118(1):7-11 - PubMed
  27. J Nutr Sci Vitaminol (Tokyo). 1987 Dec;33(6):431-8 - PubMed
  28. Diabetes. 1989 Jul;38(7):832-8 - PubMed

Publication Types