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Maeda H, Yamazaki M, Katagata Y. Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells. Exp Ther Med. 2011;3(1):49-52doi: 10.3892/etm.2011.357.
Maeda, H., Yamazaki, M., & Katagata, Y. (2012). Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells. Experimental and therapeutic medicine, 3(1), 49-52. https://doi.org/10.3892/etm.2011.357
Maeda, Hayato, et al. "Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells." Experimental and therapeutic medicine vol. 3,1 (2012): 49-52. doi: https://doi.org/10.3892/etm.2011.357
Maeda H, Yamazaki M, Katagata Y. Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells. Exp Ther Med. 2012 Jan;3(1):49-52. doi: 10.3892/etm.2011.357. Epub 2011 Sep 27. PMID: 22969843; PMCID: PMC3438748.
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Exp Ther Med. 2012 Jan;3(1):49-52. doi: 10.3892/etm.2011.357. Epub 2011 Sep 27.

Kuromoji (Lindera umbellata) essential oil-induced apoptosis and differentiation in human leukemia HL-60 cells.

Experimental and therapeutic medicine

Hayato Maeda, Mao Yamazaki, Yohtaro Katagata

Affiliations

  1. Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Aomori 036-8561, Japan.

PMID: 22969843 PMCID: PMC3438748 DOI: 10.3892/etm.2011.357

Abstract

Essential oils diluted from certain plants have been shown to have antitumor activity against several human tumor cell lines. Kuromoji (Lindera umbellata) essential oil (KEO) has long been used in Japan as a traditional medicine. KEO and its major chemical constituent, linalool, were investigated in this study for their ability to induce apoptosis and differentiation in human leukemia HL-60 cells. HL-60 cells were treated with 5 or 50 μg/ml KEO or linalool for 24 or 48 h. Then, cell proliferation and apoptosis induction were estimated. In addition, HL-60 cells are known to differentiate into granulocyte or monocytes by a variety of compounds. Therefore, the effect of KEO or linalool on differentiation of HL-60 cells was assessed by Giemsa stain and a nitroblue tetrazolium reduction assay. Cells treated with KEO or linalool for 48 h showed significantly suppressed cell proliferation, with induced apoptosis. Moreover, KEO and linalool promoted cell differentiation. Treatment with KEO cells at the same dose as linalool showed an almost identical effect on HL-60 cells. These results suggest that KEO and linalool have efficacy as anticancer therapeutic products.

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