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Bessette B, Durand K, Giraud S, et al. Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line. Exp Ther Med. 2012;3(5):873-877doi: 10.3892/etm.2012.480.
Bessette, B., Durand, K., Giraud, S., Bégaud, G., Mathonnet, M., & Lalloué, F. (2012). Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line. Experimental and therapeutic medicine, 3(5), 873-877. https://doi.org/10.3892/etm.2012.480
Bessette, Barbara, et al. "Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line." Experimental and therapeutic medicine vol. 3,5 (2012): 873-877. doi: https://doi.org/10.3892/etm.2012.480
Bessette B, Durand K, Giraud S, Bégaud G, Mathonnet M, Lalloué F. Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line. Exp Ther Med. 2012 May;3(5):873-877. doi: 10.3892/etm.2012.480. Epub 2012 Feb 13. PMID: 22969985; PMCID: PMC3438831.
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Exp Ther Med. 2012 May;3(5):873-877. doi: 10.3892/etm.2012.480. Epub 2012 Feb 13.

Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line.

Experimental and therapeutic medicine

Barbara Bessette, Karine Durand, Stéphanie Giraud, Gaëlle Bégaud, Muriel Mathonnet, Fabrice Lalloué

Affiliations

  1. University of Limoges, EA3842, 'Cellular Homeostasis and Pathology', Faculty of Medicine, 87025 Limoges Cedex;

PMID: 22969985 PMCID: PMC3438831 DOI: 10.3892/etm.2012.480

Abstract

p75(NTR), a member of the tumor necrosis factor superfamily, plays a key role in numerous physiological processes, including cell survival or apoptosis. Yet, the associated signaling pathways remain poorly understood. Similar to Notch, γ-secretase cleavage is implicated in the p75(NTR) signaling pathway leading to nuclear translocation of the intracellular domain and cell death. Fas receptor activation was found to promote cell death apoptosis in several cell lines. The goal of this study was to determine the respective role of p75(NTR) and Notch in the resistance to Fas-induced apoptosis in the U-87 MG glioblastoma cell line. Using the γ-secretase inhibitor, we investigated the modulation of Fas-induced apoptosis dependent on p75(NTR)-Fas receptor interaction. Whereas the U-87 MG cells expressed the Fas receptor at the cell membrane, apoptosis induced by Fas activation was decreased by the γ-secretase inhibitor. These data suggest that γ-secretase is implicated in p75(NTR) and Fas interaction leading to cell death signaling.

References

  1. Int J Oncol. 2009 Mar;34(3):717-27 - PubMed
  2. Arch Med Res. 2010 Oct;41(7):519-29 - PubMed
  3. Int J Oncol. 2007 Jan;30(1):273-81 - PubMed
  4. Int J Cancer. 1998 Dec 18;79(6):640-4 - PubMed
  5. Mol Cell Biol. 2000 Jun;20(11):3928-41 - PubMed
  6. Int J Oncol. 2011 Feb;38(2):391-9 - PubMed
  7. J Mammary Gland Biol Neoplasia. 2001 Jan;6(1):23-36 - PubMed
  8. PLoS Biol. 2008 Nov 25;6(11):e289 - PubMed
  9. Apoptosis. 2005 Dec;10(6):1271-83 - PubMed
  10. PLoS Biol. 2007 Aug;5(8):e212 - PubMed
  11. Neuron. 2006 Apr 20;50(2):219-32 - PubMed
  12. Neuron. 2002 May 16;34(4):499-502 - PubMed
  13. J Biol Chem. 2003 Oct 24;278(43):42161-9 - PubMed
  14. Cancer Biol Ther. 2002 Sep-Oct;1(5):466-76 - PubMed
  15. Cancer Res. 2005 Mar 15;65(6):2353-63 - PubMed
  16. Cancer Res. 1998 Sep 1;58(17):3819-25 - PubMed
  17. J Biol Chem. 2010 Feb 19;285(8):5361-8 - PubMed
  18. Science. 1999 Apr 30;284(5415):770-6 - PubMed

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