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Cohan N, Sarikhani S, Moslemi S, et al. Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures. Iran Red Crescent Med J. 2011;13(1):52-4
Cohan, N., Sarikhani, S., Moslemi, S., & Karimi, M. (2011). Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures. Iranian Red Crescent medical journal, 13(1), 52-4.
Cohan, N, et al. "Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures." Iranian Red Crescent medical journal vol. 13,1 (2011): 52-4.
Cohan N, Sarikhani S, Moslemi S, Karimi M. Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures. Iran Red Crescent Med J. 2011 Jan;13(1):52-4. Epub 2011 Jan 01. PMID: 22946019; PMCID: PMC3407586.
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Iran Red Crescent Med J. 2011 Jan;13(1):52-4. Epub 2011 Jan 01.

Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures.

Iranian Red Crescent medical journal

N Cohan, S Sarikhani, S Moslemi, M Karimi

Affiliations

  1. Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 22946019 PMCID: PMC3407586

Abstract

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate, corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the disease.

Keywords: Acute lymphoblastic leukemia; Bone fracture; Iran; Osteoporosis

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