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Int J Hepatol. 2012;2012:158547. doi: 10.1155/2012/158547. Epub 2012 Aug 29.

Cell signals influencing hepatic fibrosis.

International journal of hepatology

Min Cong, Keiko Iwaisako, Chunyan Jiang, Tatiana Kisseleva

Affiliations

  1. Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

PMID: 22973518 PMCID: PMC3437636 DOI: 10.1155/2012/158547

Abstract

Liver fibrosis is the result of the entire organism responding to a chronic injury. Every cell type in the liver contributes to the fibrosis. This paper first discusses key intracellular signaling pathways that are induced during liver fibrosis. The paper then examines the effects of these signaling pathways on the major cell types in the liver. This will provide insights into the molecular pathophysiology of liver fibrosis and should identify therapeutic targets.

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