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Solana R, Tarazona R, Aiello AE, et al. CMV and Immunosenescence: from basics to clinics. Immun Ageing. 2012;9(1):23doi: 10.1186/1742-4933-9-23.
Solana, R., Tarazona, R., Aiello, A. E., Akbar, A. N., Appay, V., Beswick, M., Bosch, J. A., Campos, C., Cantisán, S., Cicin-Sain, L., Derhovanessian, E., Ferrando-Martínez, S., Frasca, D., Fulöp, T., Govind, S., Grubeck-Loebenstein, B., Hill, A., Hurme, M., Kern, F., Larbi, A., López-Botet, M., Maier, A. B., McElhaney, J. E., Moss, P., Naumova, E., Nikolich-Zugich, J., Pera, A., Rector, J. L., Riddell, N., Sanchez-Correa, B., Sansoni, P., Sauce, D., van Lier, R., Wang, G. C., Wills, M. R., Zieliński, M., & Pawelec, G. (2012). CMV and Immunosenescence: from basics to clinics. Immunity & ageing : I & A, 9(1), 23. https://doi.org/10.1186/1742-4933-9-23
Solana, Rafael, et al. "CMV and Immunosenescence: from basics to clinics." Immunity & ageing : I & A vol. 9,1 (2012): 23. doi: https://doi.org/10.1186/1742-4933-9-23
Solana R, Tarazona R, Aiello AE, Akbar AN, Appay V, Beswick M, Bosch JA, Campos C, Cantisán S, Cicin-Sain L, Derhovanessian E, Ferrando-Martínez S, Frasca D, Fulöp T, Govind S, Grubeck-Loebenstein B, Hill A, Hurme M, Kern F, Larbi A, López-Botet M, Maier AB, McElhaney JE, Moss P, Naumova E, Nikolich-Zugich J, Pera A, Rector JL, Riddell N, Sanchez-Correa B, Sansoni P, Sauce D, van Lier R, Wang GC, Wills MR, Zieliński M, Pawelec G. CMV and Immunosenescence: from basics to clinics. Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23. PMID: 23114110; PMCID: PMC3585851.
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Immun Ageing. 2012 Oct 31;9(1):23. doi: 10.1186/1742-4933-9-23.

CMV and Immunosenescence: from basics to clinics.

Immunity & ageing : I & A

Rafael Solana, Raquel Tarazona, Allison E Aiello, Arne N Akbar, Victor Appay, Mark Beswick, Jos A Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein, Ann Hill, Mikko Hurme, Florian Kern, Anis Larbi, Miguel López-Botet, Andrea B Maier, Janet E McElhaney, Paul Moss, Elissaveta Naumova, Janko Nikolich-Zugich, Alejandra Pera, Jerrald L Rector, Natalie Riddell, Beatriz Sanchez-Correa, Paolo Sansoni, Delphine Sauce, Rene van Lier, George C Wang, Mark R Wills, Maciej Zieliński, Graham Pawelec

Affiliations

  1. Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University Hospital-University of Cordoba, Cordoba, Spain. [email protected].

PMID: 23114110 PMCID: PMC3585851 DOI: 10.1186/1742-4933-9-23

Abstract

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.

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