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Tanaka T, Kitasato S, Chazono M, et al. Use of an Injectable Complex of β-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures. Open Biomed Eng J. 2012;6:98-103doi: 10.2174/1874120701206010098.
Tanaka, T., Kitasato, S., Chazono, M., Kumagae, Y., Iida, T., Mitsuhashi, M., Kakuta, A., & Marumo, K. (2012). Use of an Injectable Complex of β-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures. The open biomedical engineering journal, 698-103. https://doi.org/10.2174/1874120701206010098
Tanaka, T, et al. "Use of an Injectable Complex of β-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures." The open biomedical engineering journal vol. 6 (2012): 98-103. doi: https://doi.org/10.2174/1874120701206010098
Tanaka T, Kitasato S, Chazono M, Kumagae Y, Iida T, Mitsuhashi M, Kakuta A, Marumo K. Use of an Injectable Complex of β-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures. Open Biomed Eng J. 2012;6:98-103. doi: 10.2174/1874120701206010098. Epub 2012 Oct 15. PMID: 23115598; PMCID: PMC3480701.
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Open Biomed Eng J. 2012;6:98-103. doi: 10.2174/1874120701206010098. Epub 2012 Oct 15.

Use of an Injectable Complex of β-Tricalcium Phosphate Granules, Hyaluronate, and Fibroblast Growth Factor-2 on Repair of Unstable Intertrochanteric Fractures.

The open biomedical engineering journal

T Tanaka, S Kitasato, M Chazono, Y Kumagae, T Iida, M Mitsuhashi, A Kakuta, K Marumo

Affiliations

  1. Department of Orthopaedic Surgery NHO, Utsunomiya National Hospital, 2160, Shimo-Okamoto, Utsunomiya City 329-1193 Tochigi, Japan.

PMID: 23115598 PMCID: PMC3480701 DOI: 10.2174/1874120701206010098

Abstract

We evaluated effects of an injectable complex of β-tricalcium phosphate (β-TCP) granules, hyaluronate, and recombinant human fibroblast growth factor-2 (rhFGF-2) on repair of unstable intertrochanteric fractures in elderly patients. Twenty-five patients (range, 76-91 years) having 31.A2 fractures (AO classification) were treated with injection of the complex followed by intramedullary nails. Bone regeneration and β-TCP resorption, unions of intertrochanteric fractures and displaced lesser trochanters to the shaft, and varus deformity of the femoral neck were assessed by X-ray and CT scans. Fracture union occurred in all cases and union of the displaced lesser trochanter to the shaft was obtained in 24 cases by 12 weeks. It is of interest that β-TCP granules were completely replaced by bone and marked new bone formation around the lesser trochanter was observed in all cases compared to cases not treated with the complex. This complex is a paste-like material that is easy to handle, and it may be of considerable use in treatment of both unstable intertrochanteric fractures and other cortical bone defects with minimal surgical invasion.

Keywords: Hyaluronate; TCP intertrochanteric; bone formation; bone union.; fractures FGF-2

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