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Haba Y, Lindner T, Fritsche A, et al. Relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis. Open Orthop J. 2012;6:458-63doi: 10.2174/1874325001206010458.
Haba, Y., Lindner, T., Fritsche, A., Schiebenhöfer, A. K., Souffrant, R., Kluess, D., Skripitz, R., Mittelmeier, W., & Bader, R. (2012). Relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis. The open orthopaedics journal, 6458-63. https://doi.org/10.2174/1874325001206010458
Haba, Yvonne, et al. "Relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis." The open orthopaedics journal vol. 6 (2012): 458-63. doi: https://doi.org/10.2174/1874325001206010458
Haba Y, Lindner T, Fritsche A, Schiebenhöfer AK, Souffrant R, Kluess D, Skripitz R, Mittelmeier W, Bader R. Relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis. Open Orthop J. 2012;6:458-63. doi: 10.2174/1874325001206010458. Epub 2012 Oct 19. PMID: 23115606; PMCID: PMC3480807.
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Open Orthop J. 2012;6:458-63. doi: 10.2174/1874325001206010458. Epub 2012 Oct 19.

Relationship between mechanical properties and bone mineral density of human femoral bone retrieved from patients with osteoarthritis.

The open orthopaedics journal

Yvonne Haba, Tobias Lindner, Andreas Fritsche, Ann-Kristin Schiebenhöfer, Robert Souffrant, Daniel Kluess, Ralf Skripitz, Wolfram Mittelmeier, Rainer Bader

Affiliations

  1. Department of Orthopaedics, Biomechanics and Implant Technology Research Laboratory, University Medicine Rostock, Germany.

PMID: 23115606 PMCID: PMC3480807 DOI: 10.2174/1874325001206010458

Abstract

The objective of this study was to analyse retrieved human femoral bone samples using three different test methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads were retrieved from 22 donors undergoing primary total hip replacement due to hip osteoarthritis and stored for a maximum of 24 hours postoperatively at + 6 °C to 8 °C.Analysis revealed an average structural modulus of 232±130 N/mm(2) and ultimate compression strength of 6.1±3.3 N/mm(2) with high standard deviations. Bone mineral densities of 385±133 mg/cm(2) and 353±172 mg/cm(3) were measured using thedual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), respectively. Ashing resulted in a bone mineral density of 323±97 mg/cm(3). In particular, significant linear correlations were found between DXA and ashing with r = 0.89 (p < 0.01, n = 22) and between structural modulus and ashing with r = 0.76 (p < 0.01, n = 22).Thus, we demonstrated a significant relationship between mechanical properties and bone density. The correlations found can help to determine the mechanical load capacity of individual patients undergoing surgical treatments by means of noninvasive bone density measurements.

Keywords: Human trabecular bone; bone mineral density; femoral head; mechanical properties.

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