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Brocker C, Thompson DC, Vasiliou V. The role of hyperosmotic stress in inflammation and disease. Biomol Concepts. 2012;3(4):345-364doi: 10.1515/bmc-2012-0001.
Brocker, C., Thompson, D. C., & Vasiliou, V. (2012). The role of hyperosmotic stress in inflammation and disease. Biomolecular concepts, 3(4), 345-364. https://doi.org/10.1515/bmc-2012-0001
Brocker, Chad, et al. "The role of hyperosmotic stress in inflammation and disease." Biomolecular concepts vol. 3,4 (2012): 345-364. doi: https://doi.org/10.1515/bmc-2012-0001
Brocker C, Thompson DC, Vasiliou V. The role of hyperosmotic stress in inflammation and disease. Biomol Concepts. 2012 Aug;3(4):345-364. doi: 10.1515/bmc-2012-0001. PMID: 22977648; PMCID: PMC3438915.
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Biomol Concepts. 2012 Aug;3(4):345-364. doi: 10.1515/bmc-2012-0001.

The role of hyperosmotic stress in inflammation and disease.

Biomolecular concepts

Chad Brocker, David C Thompson, Vasilis Vasiliou

Affiliations

  1. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

PMID: 22977648 PMCID: PMC3438915 DOI: 10.1515/bmc-2012-0001

Abstract

Hyperosmotic stress is an often overlooked process that potentially contributes to a number of human diseases. Whereas renal hyperosmolarity is a well-studied phenomenon, recent research provides evidence that many non-renal tissues routinely experience hyperosmotic stress that may contribute significantly to disease initiation and progression. Moreover, a growing body of evidence implicates hyperosmotic stress as a potent inflammatory stimulus by triggering proinflammatory cytokine release and inflammation. Under physiological conditions, the urine concentrating mechanism within the inner medullary region of the mammalian kidney exposes cells to high extracellular osmolarity. As such, renal cells have developed many adaptive strategies to compensate for increased osmolarity. Hyperosmotic stress is linked to many maladies, including acute and chronic, as well as local and systemic, inflammatory disorders. Hyperosmolarity triggers cell shrinkage, oxidative stress, protein carbonylation, mitochondrial depolarization, DNA damage, and cell cycle arrest, thus rendering cells susceptible to apoptosis. However, many adaptive mechanisms exist to counter the deleterious effects of hyperosmotic stress, including cytoskeletal rearrangement and up-regulation of antioxidant enzymes, transporters, and heat shock proteins. Osmolyte synthesis is also up-regulated and many of these compounds have been shown to reduce inflammation. The cytoprotective mechanisms and associated regulatory pathways that accompany the renal response to hyperosmolarity are found in many non-renal tissues, suggesting cells are commonly confronted with hyperosmotic conditions. Osmoadaptation allows cells to survive and function under potentially cytotoxic conditions. This review covers the pathological consequences of hyperosmotic stress in relation to disease and emphasizes the importance of considering hyperosmolarity in inflammation and disease progression.

References

  1. Am J Physiol Renal Physiol. 2001 Nov;281(5):F983-91 - PubMed
  2. Am J Physiol Cell Physiol. 2011 May;300(5):C1155-63 - PubMed
  3. Eur J Clin Nutr. 2007 Feb;61(2):190-9 - PubMed
  4. J Appl Physiol (1985). 2005 Sep;99(3):902-8 - PubMed
  5. Nephrol Dial Transplant. 2005 Mar;20(3):509-15 - PubMed
  6. Pharmacology. 1999 Oct;59(4):201-11 - PubMed
  7. Exp Eye Res. 2008 Nov;87(5):454-61 - PubMed
  8. J Biol Chem. 2008 Jun 20;283(25):17624-34 - PubMed
  9. Nutr Res. 2001 Jul;21(7):993-999 - PubMed
  10. J Exp Biol. 2005 Aug;208(Pt 15):2819-30 - PubMed
  11. J Am Diet Assoc. 2005 Aug;105(8):1231-9 - PubMed
  12. Eur J Nutr. 2009 Jun;48(4):205-12 - PubMed
  13. Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R432-R440 - PubMed
  14. Pharm Res. 2010 Aug;27(8):1620-6 - PubMed
  15. Nature. 2001 Dec 13;414(6865):799-806 - PubMed
  16. Inflammation. 2012 Apr;35(2):690-701 - PubMed
  17. Biochem J. 2004 Aug 15;382(Pt 1):177-82 - PubMed
  18. Nephrology (Carlton). 2005 Dec;10(6):576-82 - PubMed
  19. J Biol Chem. 2007 Mar 2;282(9):6644-52 - PubMed
  20. Exp Eye Res. 2006 Oct;83(4):939-48 - PubMed
  21. Biochem Biophys Res Commun. 2001 Jul 27;285(4):1066-70 - PubMed
  22. BMC Mol Biol. 2008 Jan 25;9:13 - PubMed
  23. Nucleic Acids Res. 2011 Jan;39(2):475-85 - PubMed
  24. Acta Anaesthesiol Scand. 2006 Sep;50(8):970-7 - PubMed
  25. Arthritis Res Ther. 2010;12(3):R100 - PubMed
  26. Biochim Biophys Acta. 2009 Jun;1794(6):929-35 - PubMed
  27. Nat Rev Neurosci. 2008 Jul;9(7):519-31 - PubMed
  28. FEBS Lett. 2005 Oct 10;579(24):5430-6 - PubMed
  29. J Biomed Sci. 2010 Aug 24;17 Suppl 1:S2 - PubMed
  30. J Clin Invest. 2009 Jun;119(6):1647-58 - PubMed
  31. Exp Neurol. 2010 Nov;226(1):110-9 - PubMed
  32. Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):485-93 - PubMed
  33. Am J Physiol Renal Physiol. 2005 Sep;289(3):F506-11 - PubMed
  34. Expert Rev Endocrinol Metab. 2010 Jul 1;5(4):603-614 - PubMed
  35. ScientificWorldJournal. 2011 Jul 28;11:1536-47 - PubMed
  36. Nephron. 1998;78(1):28-32 - PubMed
  37. Curr Pharm Biotechnol. 2011 Mar 1;12(3):373-85 - PubMed
  38. J Physiol. 2010 Sep 15;588(Pt 18):3375-84 - PubMed
  39. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10673-8 - PubMed
  40. Crit Care. 2008;12(4):R107 - PubMed
  41. Trends Neurosci. 2010 Feb;33(2):76-83 - PubMed
  42. Biol Chem. 2010 Oct;391(10):1175-87 - PubMed
  43. Lancet. 1993 May 22;341(8856):1330-2 - PubMed
  44. Am J Clin Nutr. 2008 Feb;87(2):424-30 - PubMed
  45. J Biol Chem. 2010 Dec 31;285(53):41280-9 - PubMed
  46. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2287-96 - PubMed
  47. Diabetes Care. 2003 Nov;26(11):3129-35 - PubMed
  48. Curr Drug Metab. 2004 Jun;5(3):273-82 - PubMed
  49. Life Sci. 2007 May 8;80(22):2085-92 - PubMed
  50. J Physiol. 2006 Oct 15;576(Pt 2):391-401 - PubMed
  51. Diabetes Metab. 2003 Dec;29(6):566-75 - PubMed
  52. Am J Physiol Endocrinol Metab. 2000 Dec;279(6):E1207-15 - PubMed
  53. Eur J Epidemiol. 2004;19(10):935-44 - PubMed
  54. Biochem Biophys Res Commun. 2008 Jul 25;372(2):326-30 - PubMed
  55. EMBO J. 2010 Aug 4;29(15):2501-14 - PubMed
  56. Zhonghua Yi Xue Za Zhi. 2011 Mar 1;91(8):549-53 - PubMed
  57. Pflugers Arch. 2001 Jul;442(4):614-21 - PubMed
  58. Neuron. 2011 Jan 27;69(2):332-44 - PubMed
  59. Biochem Biophys Res Commun. 2010 Jun 4;396(3):656-61 - PubMed
  60. Life Sci. 2011 Jan 17;88(3-4):117-25 - PubMed
  61. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):883-93 - PubMed
  62. Am J Ophthalmol. 2011 May;151(5):792-798.e1 - PubMed
  63. Biochim Biophys Acta. 2000 Jun 1;1475(1):39-46 - PubMed
  64. Arch Biochem Biophys. 2002 May 15;401(2):187-97 - PubMed
  65. Gut. 1982 Apr;23(4):326-32 - PubMed
  66. J Mol Biol. 2001 Jul 27;310(5):955-63 - PubMed
  67. J Am Soc Nephrol. 2003 Aug;14(8 Suppl 3):S233-6 - PubMed
  68. Am J Physiol Renal Physiol. 2011 Mar;300(3):F707-15 - PubMed
  69. J Biol Chem. 2010 Oct 8;285(41):31694-703 - PubMed
  70. Mol Cell Biol. 2002 Aug;22(16):5753-60 - PubMed
  71. Invest Ophthalmol Vis Sci. 1993 Jun;34(7):2352-9 - PubMed
  72. J Biol Chem. 2008 Sep 5;283(36):25082-90 - PubMed
  73. Biochim Biophys Acta. 2011 Mar;1814(3):435-48 - PubMed
  74. J Biol Chem. 2003 Oct 3;278(40):38484-94 - PubMed
  75. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51 - PubMed
  76. Arthritis Rheum. 2010 Oct;62(10):2973-83 - PubMed
  77. FASEB J. 2010 Nov;24(11):4325-35 - PubMed
  78. Nat Rev Immunol. 2007 Sep;7(9):690-702 - PubMed
  79. Am J Physiol. 1979 Jun;236(6):E603-9 - PubMed
  80. J Inflamm (Lond). 2009 Jun 23;6:21 - PubMed
  81. Curr Genomics. 2007 Jun;8(4):209-18 - PubMed
  82. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13672-7 - PubMed
  83. J Biol Chem. 2006 Aug 18;281(33):23870-9 - PubMed
  84. J Am Soc Nephrol. 2006 Jun;17(6):1521-31 - PubMed
  85. J Investig Med. 1997 Feb;45(2):50-6 - PubMed
  86. Chem Biol Interact. 2011 May 30;191(1-3):269-77 - PubMed
  87. J Mol Cell Cardiol. 2009 Sep;47(3):382-90 - PubMed
  88. Biochemistry. 1993 Jan 12;32(1):137-44 - PubMed
  89. Arch Oral Biol. 2009 Aug;54(8):749-56 - PubMed
  90. Am J Pathol. 2002 Sep;161(3):987-96 - PubMed
  91. Exp Mol Pathol. 2011 Oct;91(2):540-7 - PubMed
  92. J Cell Biochem. 2001 Jun 26-Jul 25;83(1):56-69 - PubMed
  93. Inflamm Res. 2008 Sep;57(9):419-29 - PubMed
  94. Exp Eye Res. 2006 Apr;82(4):588-96 - PubMed
  95. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1328-38 - PubMed
  96. Am J Physiol Cell Physiol. 2009 Mar;296(3):C463-75 - PubMed
  97. Biochem J. 2003 Apr 15;371(Pt 2):609-19 - PubMed
  98. Dig Dis Sci. 1988 Nov;33(11):1353-8 - PubMed
  99. J Cell Biochem. 2010 Mar 1;109(4):663-71 - PubMed
  100. J Clin Invest. 1993 Aug;92(2):617-23 - PubMed
  101. FASEB J. 2006 Mar;20(3):574-6 - PubMed
  102. Chem Biol Interact. 2011 May 30;191(1-3):330-8 - PubMed
  103. Biochimie. 2004 Aug;86(8):533-41 - PubMed
  104. Physiol Rev. 2007 Oct;87(4):1441-74 - PubMed
  105. EMBO J. 2006 Jul 12;25(13):3033-44 - PubMed
  106. Methods Enzymol. 2007;428:313-24 - PubMed
  107. Apoptosis. 2010 Jul;15(7):822-33 - PubMed
  108. Comp Biochem Physiol A Mol Integr Physiol. 2001 Oct;130(3):411-20 - PubMed
  109. Biotechnol Bioeng. 2010 Apr 15;105(6):1187-92 - PubMed
  110. Exp Diabetes Res. 2007;2007:61038 - PubMed
  111. Crit Care Med. 2011 Nov;39(11):2550-3 - PubMed
  112. Biophys Chem. 2005 Aug 22;117(1):1-12 - PubMed
  113. J Biol Chem. 2010 Jun 11;285(24):18452-63 - PubMed
  114. Immunity. 2001 Jul;15(1):47-58 - PubMed
  115. Best Pract Res Clin Endocrinol Metab. 2003 Dec;17(4):471-503 - PubMed
  116. Biochem J. 1995 Nov 15;312 ( Pt 1):135-43 - PubMed
  117. Kidney Int. 2011 Nov;80(9):938-945 - PubMed
  118. Am J Physiol Cell Physiol. 2003 Jan;284(1):C200-8 - PubMed
  119. Am J Cardiol. 1976 Feb;37(2):269-82 - PubMed
  120. Biochem J. 1992 Dec 1;288 ( Pt 2):681-9 - PubMed
  121. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1089-98 - PubMed
  122. Curr Genomics. 2010 Dec;11(8):584-90 - PubMed
  123. J Am Soc Nephrol. 2003 Feb;14(2):283-8 - PubMed
  124. Nat Med. 2009 May;15(5):545-52 - PubMed
  125. J Immunol. 2007 Sep 15;179(6):3604-12 - PubMed
  126. Sci Signal. 2009 Apr 07;2(65):pe20 - PubMed
  127. J Biol Chem. 2003 Nov 7;278(45):44525-34 - PubMed
  128. Hepatology. 1999 Jan;29(1):173-80 - PubMed
  129. Cerebrospinal Fluid Res. 2009 Dec 11;6:16 - PubMed
  130. Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C1-8 - PubMed
  131. Am J Physiol Cell Physiol. 2009 Jan;296(1):C75-87 - PubMed
  132. Acta Physiol (Oxf). 2006 May-Jun;187(1-2):199-203 - PubMed
  133. J Immunol. 2010 Dec 1;185(11):6624-35 - PubMed
  134. Mol Pharmacol. 2007 Oct;72(4):826-37 - PubMed
  135. Clin Diagn Lab Immunol. 2005 Nov;12(11):1285-91 - PubMed
  136. J Biol Chem. 2003 Jul 18;278(29):26550-7 - PubMed
  137. J Immunol. 2010 May 1;184(9):5253-62 - PubMed
  138. J Biol Chem. 2000 Jul 28;275(30):23281-6 - PubMed
  139. FEBS Lett. 2006 Aug 7;580(18):4495-500 - PubMed
  140. Cell Physiol Biochem. 2011;28(6):1111-22 - PubMed
  141. Toxicol Appl Pharmacol. 2004 Sep 15;199(3):316-31 - PubMed
  142. Hepatol Res. 2004 Jan;28(1):1-11 - PubMed
  143. J Biol Chem. 1998 Aug 7;273(32):20615-21 - PubMed
  144. J Immunol. 2002 Nov 15;169(10):5477-88 - PubMed
  145. J Am Soc Nephrol. 2005 Mar;16(3):600-7 - PubMed
  146. Arch Biochem Biophys. 2003 May 15;413(2):151-7 - PubMed
  147. FEBS Lett. 1997 Jun 30;410(2-3):201-5 - PubMed
  148. Pediatr Endocrinol Rev. 2006 Dec;4 Suppl 1:60-5 - PubMed
  149. Mol Biol Cell. 2011 Mar 1;22(5):703-14 - PubMed
  150. Am J Clin Nutr. 2008 Feb;87(2):277-8 - PubMed
  151. J Leukoc Biol. 2008 Sep;84(3):607-13 - PubMed
  152. DNA Repair (Amst). 2009 Aug 6;8(8):930-43 - PubMed
  153. J Mol Cell Cardiol. 2008 May;44(5):927-37 - PubMed
  154. Wien Med Wochenschr. 2008;158(19-20):549-52 - PubMed
  155. Mol Cell Proteomics. 2010 Dec;9(12):2853-63 - PubMed
  156. Biochem J. 1992 Oct 1;287 ( Pt 1):217-22 - PubMed
  157. J Androl. 2011 Jul-Aug;32(4):402-10 - PubMed
  158. J Biochem. 2004 Sep;136(3):267-72 - PubMed
  159. Invest Ophthalmol Vis Sci. 2008 May;49(5):1827-35 - PubMed
  160. J Biol Chem. 2009 Jan 16;284(3):1484-94 - PubMed
  161. Mol Cell Biol. 2005 Apr;25(7):2733-43 - PubMed
  162. Arthritis Rheum. 2011 Jul;63(7):1843-52 - PubMed
  163. J Biol Chem. 2007 Jan 12;282(2):1152-60 - PubMed

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