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Kang HJ, Kim CH, Park DS, et al. The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65. Ann Rehabil Med. 2012;36(4):433-46doi: 10.5535/arm.2012.36.4.433.
Kang, H. J., Kim, C. H., Park, D. S., Choi, S. Y., Lee, D. H., Nam, H. S., Hur, J. G., & Woo, J. H. (2012). The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65. Annals of rehabilitation medicine, 36(4), 433-46. https://doi.org/10.5535/arm.2012.36.4.433
Kang, Hyeon-Jung, et al. "The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65." Annals of rehabilitation medicine vol. 36,4 (2012): 433-46. doi: https://doi.org/10.5535/arm.2012.36.4.433
Kang HJ, Kim CH, Park DS, Choi SY, Lee DH, Nam HS, Hur JG, Woo JH. The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65. Ann Rehabil Med. 2012 Aug;36(4):433-46. doi: 10.5535/arm.2012.36.4.433. Epub 2012 Aug 27. PMID: 22977768; PMCID: PMC3438409.
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Ann Rehabil Med. 2012 Aug;36(4):433-46. doi: 10.5535/arm.2012.36.4.433. Epub 2012 Aug 27.

The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65.

Annals of rehabilitation medicine

Hyeon-Jung Kang, Chul-Hyun Kim, Dong-Sik Park, Seung-Yeon Choi, Dong-Hoon Lee, Hee-Seung Nam, Jin-Gang Hur, Ji-Hea Woo

Affiliations

  1. Department of Rehabilitation Medicine, Hallym University College of Medicine, Seoul 134-701, Korea.

PMID: 22977768 PMCID: PMC3438409 DOI: 10.5535/arm.2012.36.4.433

Abstract

OBJECTIVE: To investigate associations between angiotensin-converting enzyme (ACE) polymorphisms and muscle fatigability in 65-year-old Koreans.

METHOD: The study participants were 49 Koreans aged 65 years. ACE insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction and serum ACE activity, by spectrophotometry. Body mass index (BMI), body fat mass (BFM), and lean body mass (LBM) were determined. To evaluate muscle fatigability, dynamic Electromyography was used to measure maximum voluntary isometric contractions (MVICs) of ankle plantar flexor muscles. Patients were seated with their hips flexed at 90°, knees fully extended, and ankles at 0°. Continuous submaximal VICs (40% MVIC) were then performed, and contraction duration and EMG frequency changes during the initial 2 min were measured. A self-reported physical activity questionnaire was used to evaluate effects of ACE activity levels on muscle fatigability.

RESULTS: Among the 49 volunteers, 15 showed II genotype; 22, ID genotype; and 12, DD genotype. Serum ACE activity levels were significantly higher in DD genotype subjects than in II genotype subjects (p<0.05). Furthermore, the duration of submaximal isometric contractions was longer in II and ID genotype subjects than in DD genotype subjects (p<0.05). Dynamic EMG showed significantly lower mean frequency changes in II genotype subjects than in DD genotype subjects (p<0.05). However, LBM, BFM, and BMI were independent of ACE genotypes.

CONCLUSION: ACE II genotype subjects showed significantly higher resistant to muscle fatigue than that by DD genotype subjects. However, body composition and BMI showed no correlations with ACE I/D polymorphisms.

Keywords: Angiotensin converting enzyme; Body composition; Muscle fatigue; Polymorphism

References

  1. Spine (Phila Pa 1976). 1994 Jun 1;19(11):1223-9 - PubMed
  2. Ciba Found Symp. 1981;82:1-18 - PubMed
  3. Mech Ageing Dev. 2003 Mar;124(3):287-99 - PubMed
  4. Arch Phys Med Rehabil. 1996 Mar;77(3):259-64 - PubMed
  5. J Long Term Eff Med Implants. 2006;16(2):193-204 - PubMed
  6. J Renin Angiotensin Aldosterone Syst. 2008 Jun;9(2):75-88 - PubMed
  7. Eur J Appl Physiol. 2005 Aug;94(5-6):611-7 - PubMed
  8. J Physiol. 1993 Jan;460:549-72 - PubMed
  9. Clin Cancer Res. 2009 Apr 1;15(7):2442-7 - PubMed
  10. Ann Epidemiol. 2003 Jan;13(1):57-65 - PubMed
  11. Acta Physiol Scand. 1983 Sep;119(1):61-7 - PubMed
  12. J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):1337-43 - PubMed
  13. J Orthop Sports Phys Ther. 1996 Dec;24(6):342-53 - PubMed
  14. J Appl Physiol Respir Environ Exerc Physiol. 1981 Jul;51(1):1-7 - PubMed
  15. J Clin Invest. 1990 Oct;86(4):1343-6 - PubMed
  16. J Electromyogr Kinesiol. 2000 Oct;10(5):361-74 - PubMed
  17. Gerontology. 2006;52(4):237-42 - PubMed
  18. Eur J Appl Physiol Occup Physiol. 1990;60(2):104-11 - PubMed
  19. Hypertension. 2000 Mar;35(3):764-8 - PubMed
  20. Am J Clin Nutr. 2005 May;81(5):953-63 - PubMed
  21. Hum Genet. 2001 Mar;108(3):230-2 - PubMed
  22. Exerc Sport Sci Rev. 2002 Oct;30(4):184-90 - PubMed
  23. Clin Chem. 1981 Nov;27(11):1922-5 - PubMed
  24. Eur J Appl Physiol. 2000 May;82(1-2):117-20 - PubMed
  25. J Electromyogr Kinesiol. 2009 Jun;19(3):484-91 - PubMed
  26. Br J Cancer. 2005 Aug 22;93(4):425-34 - PubMed
  27. Med Sci Sports Exerc. 2006 Nov;38(11):1863-88 - PubMed
  28. Eur J Hum Genet. 2001 Oct;9(10):797-801 - PubMed
  29. J Appl Physiol (1985). 1999 Oct;87(4):1313-6 - PubMed

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