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Int J Hepatol. 2012;2012:264015. doi: 10.1155/2012/264015. Epub 2012 Oct 02.

Experience Since MELD Implementation: How Does the New System Deliver?.

International journal of hepatology

Markus Quante, Christoph Benckert, Armin Thelen, Sven Jonas

Affiliations

  1. Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Liebigstr. 20, 04103 Leipzig, Germany.

PMID: 23091734 PMCID: PMC3467768 DOI: 10.1155/2012/264015

Abstract

Because of increasing waiting-list mortality, the MELD (Model for End-Stage Liver Disease) allocation system was implemented within most countries of the Eurotransplant area on December 16, 2006. Five years have now passed, and we review in this paper the effects of the MELD-based allocation upon the waiting list for liver transplantation, on peri-operative management and on postoperative outcome. Giving priority to sicker patients on the waiting list has resulted in a significant increase in mean MELD score at the time of organ allocation. Consequently, there has also been a significant reduction in waiting-list mortality. However, in Germany a worsening in postoperative outcome, mainly in the group of high-MELD recipients (≥30 points), has been reported. This paper presents comprehensive results following liver transplantation within the MELD era. Especially for the group of high-risk recipients, risk factors for impaired survival are presented and discussed.

References

  1. Liver Transpl. 2012 Jan;18(1):112-9 - PubMed
  2. Liver Transpl. 2011 Jun;17(6):674-84 - PubMed
  3. Curr Opin Gastroenterol. 2010 May;26(3):209-13 - PubMed
  4. Transplant Proc. 2011 Dec;43(10):3762-8 - PubMed
  5. Chirurg. 2008 Feb;79(2):157-63 - PubMed
  6. Am J Transplant. 2008 Apr;8(4 Pt 2):958-76 - PubMed
  7. Liver Transpl. 2006 Mar;12(3):440-7 - PubMed
  8. Scand J Gastroenterol. 2011 Jul;46(7-8):941-8 - PubMed
  9. N Engl J Med. 2008 Sep 4;359(10):1018-26 - PubMed
  10. Am J Transplant. 2006 Apr;6(4):783-90 - PubMed
  11. Am J Transplant. 2011 Nov;11(11):2362-71 - PubMed
  12. Transpl Int. 2009 Jul;22(7):702-6 - PubMed
  13. Transpl Int. 2009 Oct;22(10):970-8 - PubMed
  14. Scand J Gastroenterol. 2008;43(6):736-46 - PubMed
  15. Z Gastroenterol. 2011 Jan;49(1):30-8 - PubMed
  16. Transplant Proc. 2008 Apr;40(3):797-9 - PubMed
  17. Am J Transplant. 2008 Feb;8(2):419-25 - PubMed
  18. Transplantation. 2006 Dec 27;82(12):1653-7 - PubMed
  19. Am J Transplant. 2010 Dec;10(12):2652-7 - PubMed
  20. Hepatology. 2000 Apr;31(4):864-71 - PubMed
  21. Am J Transplant. 2008 Dec;8(12):2537-46 - PubMed
  22. Transpl Int. 2011 Jan;24(1):91-9 - PubMed
  23. Clin Liver Dis. 2007 May;11(2):417-29 - PubMed
  24. Gastroenterology. 2008 Nov;135(5):1568-74 - PubMed
  25. Ann Surg. 2010 Jan;251(1):153-7 - PubMed
  26. Liver Transpl. 2003 Feb;9(2):117-23 - PubMed

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