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Kroesen M, Maseland M, Smal J, et al. Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome. J Pediatr Pharmacol Ther. 2012;17(1):93-7doi: 10.5863/1551-6776-17.1.93.
Kroesen, M., Maseland, M., Smal, J., Reimer, A., & van Setten, P. (2012). Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 17(1), 93-7. https://doi.org/10.5863/1551-6776-17.1.93
Kroesen, Michiel, et al. "Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 17,1 (2012): 93-7. doi: https://doi.org/10.5863/1551-6776-17.1.93
Kroesen M, Maseland M, Smal J, Reimer A, van Setten P. Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome. J Pediatr Pharmacol Ther. 2012 Jan;17(1):93-7. doi: 10.5863/1551-6776-17.1.93. PMID: 23118663; PMCID: PMC3428194.
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J Pediatr Pharmacol Ther. 2012 Jan;17(1):93-7. doi: 10.5863/1551-6776-17.1.93.

Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Michiel Kroesen, Machiel Maseland, Jaime Smal, Annet Reimer, Petra van Setten

Affiliations

  1. Department of Pediatrics and Department of Clinical Pharmacy, Rijnstate Hospital, Wagnerlaan, Arnhem, The Netherlands ; Department of Pediatric Cardiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

PMID: 23118663 PMCID: PMC3428194 DOI: 10.5863/1551-6776-17.1.93

Abstract

We present the case of a 2-year-old asthmatic boy with atrioventricular (AV)-reentry tachycardia following albuterol inhalation, who was later diagnosed with Wolff-Parkinson-White (WPW) syndrome. The Naranjo adverse drug reaction probability scale score for this adverse event was 7, indicating that the association between his AV-reentry tachycardia and inhalation of albuterol is probable. To our knowledge, this is the first case report that shows the potential arrhythmogenic effects of albuterol in a child with WPW syndrome. We urge clinicians to be aware of this potentially life-threatening adverse effect and to closely monitor these patients when they need beta-adrenergic drugs in case of emergency. Furthermore, this report highlights the dilemma regarding the safe treatment of pediatric patients with both asthma and WPW syndrome.

Keywords: Wolff-Parkinson-White syndrome; adverse drug effect; albuterol; arrhythmias; asthma

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