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Ruohonen ST, Vähätalo LH, Savontaus E. Diet-induced obesity in mice overexpressing neuropeptide y in noradrenergic neurons. Int J Pept. 2012;2012:452524doi: 10.1155/2012/452524.
Ruohonen, S. T., Vähätalo, L. H., & Savontaus, E. (2012). Diet-induced obesity in mice overexpressing neuropeptide y in noradrenergic neurons. International journal of peptides, 2012452524. https://doi.org/10.1155/2012/452524
Ruohonen, Suvi T, et al. "Diet-induced obesity in mice overexpressing neuropeptide y in noradrenergic neurons." International journal of peptides vol. 2012 (2012): 452524. doi: https://doi.org/10.1155/2012/452524
Ruohonen ST, Vähätalo LH, Savontaus E. Diet-induced obesity in mice overexpressing neuropeptide y in noradrenergic neurons. Int J Pept. 2012;2012:452524. doi: 10.1155/2012/452524. Epub 2012 Oct 18. PMID: 23118773; PMCID: PMC3483820.
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Int J Pept. 2012;2012:452524. doi: 10.1155/2012/452524. Epub 2012 Oct 18.

Diet-induced obesity in mice overexpressing neuropeptide y in noradrenergic neurons.

International journal of peptides

Suvi T Ruohonen, Laura H Vähätalo, Eriika Savontaus

Affiliations

  1. Department of Pharmacology, Drug Development, and Therapeutics and Turku Center for Disease Modeling, University of Turku, Itäinen Pitkäkatu 4B, 20520 Turku, Finland.

PMID: 23118773 PMCID: PMC3483820 DOI: 10.1155/2012/452524

Abstract

Neuropeptide Y (NPY) is a neurotransmitter associated with feeding and obesity. We have constructed an NPY transgenic mouse model (OE-NPY(DBH) mouse), where targeted overexpression leads to increased levels of NPY in noradrenergic and adrenergic neurons. We previously showed that these mice become obese on a normal chow. Now we aimed to study the effect of a Western-type diet in OE-NPY(DBH) and wildtype (WT) mice, and to compare the genotype differences in the development of obesity, insulin resistance, and diabetes. Weight gain, glucose, and insulin tolerance tests, fasted plasma insulin, and cholesterol levels were assayed. We found that female OE-NPY(DBH) mice gained significantly more weight without hyperphagia or decreased activity, and showed larger white and brown fat depots with no difference in UCP-1 levels. They also displayed impaired glucose tolerance and decreased insulin sensitivity. OE-NPY(DBH) and WT males gained weight robustly, but no difference in the degree of adiposity was observed. However, 40% of OE-NPY(DBH) but none of the WT males developed hyperglycaemia while on the diet. The present study shows that female OE-NPY(DBH) mice were not protected from the obesogenic effect of the diet suggesting that increased NPY release may predispose females to a greater risk of weight gain under high caloric conditions.

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