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Knirel YA, Anisimov AP. Lipopolysaccharide of Yersinia pestis, the Cause of Plague: Structure, Genetics, Biological Properties. Acta Naturae. 2012;4(3):46-58
Knirel, Y. A., & Anisimov, A. P. (2012). Lipopolysaccharide of Yersinia pestis, the Cause of Plague: Structure, Genetics, Biological Properties. Acta naturae, 4(3), 46-58.
Knirel, Y A, and Anisimov, A P. "Lipopolysaccharide of Yersinia pestis, the Cause of Plague: Structure, Genetics, Biological Properties." Acta naturae vol. 4,3 (2012): 46-58.
Knirel YA, Anisimov AP. Lipopolysaccharide of Yersinia pestis, the Cause of Plague: Structure, Genetics, Biological Properties. Acta Naturae. 2012 Jul;4(3):46-58. PMID: 23150803; PMCID: PMC3492934.
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Acta Naturae. 2012 Jul;4(3):46-58.

Lipopolysaccharide of Yersinia pestis, the Cause of Plague: Structure, Genetics, Biological Properties.

Acta naturae

Y A Knirel, A P Anisimov

Affiliations

  1. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect, 47, Moscow, Russia, 119991.

PMID: 23150803 PMCID: PMC3492934

Abstract

The present review summarizes data pertaining to the composition and structure of the carbohydrate moiety (core oligosaccharide) and lipid component (lipid A) of the various forms of lipopolysaccharide (LPS), one of the major pathogenicity factors ofYersinia pestis, the cause of plague. The review addresses the functions and the biological significance of genes for the biosynthesis of LPS, as well as the biological properties of LPS in strains from various intraspecies groups ofY. pestis and their mutants, including the contribution of LPS to the resistance of bacteria to factors of the innate immunity of both insect-vectors and mammal-hosts. Special attention is paid to temperature-dependent variations in the LPS structure, their genetic control and roles in the pathogenesis of plague. The evolutionary aspect is considered based on a comparison of the structure and genetics of the LPS ofY. pestis and other enteric bacteria, including otherYersinia species. The prospects of development of live plague vaccines created on the basis ofY. pestis strains with the genetically modified LPS are discussed.

Keywords: Yersinia pestis; antibiotic resistance; immune response; lipid A; lipopolysaccharide; plague

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