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Battiprolu PK, Lopez-Crisosto C, Wang ZV, et al. Diabetic cardiomyopathy and metabolic remodeling of the heart. Life Sci. 2012;92(11):609-15doi: 10.1016/j.lfs.2012.10.011.
Battiprolu, P. K., Lopez-Crisosto, C., Wang, Z. V., Nemchenko, A., Lavandero, S., & Hill, J. A. (2013). Diabetic cardiomyopathy and metabolic remodeling of the heart. Life sciences, 92(11), 609-15. https://doi.org/10.1016/j.lfs.2012.10.011
Battiprolu, Pavan K, et al. "Diabetic cardiomyopathy and metabolic remodeling of the heart." Life sciences vol. 92,11 (2013): 609-15. doi: https://doi.org/10.1016/j.lfs.2012.10.011
Battiprolu PK, Lopez-Crisosto C, Wang ZV, Nemchenko A, Lavandero S, Hill JA. Diabetic cardiomyopathy and metabolic remodeling of the heart. Life Sci. 2013 Mar 28;92(11):609-15. doi: 10.1016/j.lfs.2012.10.011. Epub 2012 Oct 30. PMID: 23123443; PMCID: PMC3593804.
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Life Sci. 2013 Mar 28;92(11):609-15. doi: 10.1016/j.lfs.2012.10.011. Epub 2012 Oct 30.

Diabetic cardiomyopathy and metabolic remodeling of the heart.

Life sciences

Pavan K Battiprolu, Camila Lopez-Crisosto, Zhao V Wang, Andriy Nemchenko, Sergio Lavandero, Joseph A Hill

Affiliations

  1. Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

PMID: 23123443 PMCID: PMC3593804 DOI: 10.1016/j.lfs.2012.10.011

Abstract

The incidence and prevalence of diabetes mellitus are both increasing rapidly in societies around the globe. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic disease and hypertension. However, the diabetic milieu is itself intrinsically noxious to the heart, and cardiomyopathy can develop independent of elevated blood pressure or coronary artery disease. This process, termed diabetic cardiomyopathy, is characterized by significant changes in the physiology, structure, and mechanical function of the heart. Presently, therapy for patients with diabetes focuses largely on glucose control, and attention to the heart commences with the onset of symptoms. When the latter develops, standard therapy for heart failure is applied. However, recent studies highlight that specific elements of the pathogenesis of diabetic heart disease are unique, raising the prospect of diabetes-specific therapeutic intervention. Here, we review recently unveiled insights into the pathogenesis of diabetic cardiomyopathy and associated metabolic remodeling with an eye toward identifying novel targets with therapeutic potential.

Published by Elsevier Inc.

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