Display options
Cite
Vaughan K, Kim Y, Sette A. A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts. Autoimmune Dis. 2012;2012:403915doi: 10.1155/2012/403915.
Vaughan, K., Kim, Y., & Sette, A. (2012). A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts. Autoimmune diseases, 2012403915. https://doi.org/10.1155/2012/403915
Vaughan, Kerrie, et al. "A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts." Autoimmune diseases vol. 2012 (2012): 403915. doi: https://doi.org/10.1155/2012/403915
Vaughan K, Kim Y, Sette A. A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts. Autoimmune Dis. 2012;2012:403915. doi: 10.1155/2012/403915. Epub 2012 Dec 02. PMID: 23243503; PMCID: PMC3518085.
Copy Download .nbib Format: NLM
Share it on

Autoimmune Dis. 2012;2012:403915. doi: 10.1155/2012/403915. Epub 2012 Dec 02.

A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts.

Autoimmune diseases

Kerrie Vaughan, Yohan Kim, Alessandro Sette

Affiliations

  1. Immune Epitope Database (IEDB), La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

PMID: 23243503 PMCID: PMC3518085 DOI: 10.1155/2012/403915

Abstract

Here we analyzed the molecular targets associated with myasthenia gravis (MG) immune responses, enabled by an immune epitope database (IEDB) inventory of approximately 600 MG-related epitopes derived from 175 references. The vast majority of epitopes were derived from the α-subunit of human AChR suggesting that other MG-associated autoantigens should be investigated further. Human α-AChR was mostly characterized in humans, whereas reactivity primarily to T. californica AChR was examined in animal models. While the fine specificity of T-cell response was similar in the two systems, substantial antibody reactivity to the C-terminus was detected in the nonhuman system, but not in humans. Further analysis showed that the reactivity of nonhuman hosts to the C-terminus was eliminated when data were restricted to hosts tested in the context of autoimmune disease (spontaneous or induced), demonstrating that the epitopes recognized in humans and animals were shared when disease was present. Finally, we provided data subsets relevant to particular applications, including those associated with HLA typing or restriction, sets of epitopes recognized by monoclonal antibodies, and epitopes associated with modulation of immunity or disease. In conclusion, this analysis highlights gaps, differences, and similarities in the epitope repertoires of humans and animal models.

References

  1. J Mol Neurosci. 2010 Jan;40(1-2):217-20 - PubMed
  2. Neuron. 1995 Aug;15(2):323-31 - PubMed
  3. Ann N Y Acad Sci. 2003 Sep;998:375-8 - PubMed
  4. J Autoimmun. 1997 Aug;10(4):401-6 - PubMed
  5. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20365-70 - PubMed
  6. Ann N Y Acad Sci. 1987;505:439-50 - PubMed
  7. Vet Immunol Immunopathol. 1999 Aug 2;69(2-4):239-49 - PubMed
  8. Viral Immunol. 2010 Jun;23(3):259-84 - PubMed
  9. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):246-51 - PubMed
  10. Ann N Y Acad Sci. 2003 Sep;998:237-56 - PubMed
  11. Future Microbiol. 2010 Feb;5(2):221-39 - PubMed
  12. J Allergy (Cairo). 2010;2010:628026 - PubMed
  13. Med Arh. 2010;64(1):7-10 - PubMed
  14. Ann N Y Acad Sci. 1976;274:283-99 - PubMed
  15. Nat Med. 2001 Mar;7(3):365-8 - PubMed
  16. Ann Neurol. 2010 Apr;67(4):441-51 - PubMed
  17. BMC Bioinformatics. 2011 Dec 19;12:482 - PubMed
  18. J Clin Invest. 1989 Oct;84(4):1174-80 - PubMed
  19. J Clin Invest. 1997 Dec 15;100(12):3027-35 - PubMed
  20. J Autoimmun. 1992 Apr;5(2):213-27 - PubMed
  21. Ann N Y Acad Sci. 1998 May 13;841:262-82 - PubMed
  22. Immunogenetics. 1985;21(1):33-8 - PubMed
  23. Immunol Rev. 1998 Jun;163:89-120 - PubMed
  24. J Neuroimmunol. 2002 May;126(1-2):99-106 - PubMed
  25. Adv Neuroimmunol. 1994;4(4):387-402 - PubMed
  26. J Immunol. 1982 Mar;128(3):1141-4 - PubMed
  27. PLoS One. 2009 Sep 14;4(9):e6948 - PubMed
  28. Expert Rev Vaccines. 2008 Feb;7(1):55-74 - PubMed
  29. Adv Immunol. 1988;42:233-84 - PubMed
  30. J Immunol Methods. 2001 May 1;251(1-2):177-86 - PubMed
  31. Parasite Immunol. 2009 Feb;31(2):78-97 - PubMed
  32. Proc Natl Acad Sci U S A. 1988 May;85(9):2899-903 - PubMed
  33. Proc Natl Acad Sci U S A. 1982 Jan;79(1):188-92 - PubMed
  34. J Lab Clin Med. 1994 Aug;124(2):231-41 - PubMed
  35. J Neuroimmunol. 1998 Nov 2;91(1-2):82-8 - PubMed
  36. Hum Immunol. 2000 Mar;61(3):255-65 - PubMed
  37. Clin Immunol. 2000 Feb;94(2):75-87 - PubMed
  38. Muscle Nerve. 2000 Apr;23(4):453-77 - PubMed
  39. J Immunol. 1996 Oct 1;157(7):3192-9 - PubMed
  40. Neuroepidemiology. 2010;34(3):171-83 - PubMed
  41. FEBS J. 2007 Aug;274(15):3799-845 - PubMed
  42. J Autoimmun. 2001 Nov;17(3):175-80 - PubMed
  43. Cytometry A. 2008 Nov;73(11):1066-70 - PubMed
  44. Science. 1973 May 25;180(4088):871-2 - PubMed
  45. J Neuroimmunol. 2008 Sep 15;201-202:41-9 - PubMed
  46. Mol Immunol. 2008 Nov;46(1):192-201 - PubMed
  47. Am J Pathol. 1992 May;140(5):1215-23 - PubMed
  48. Clin Exp Immunol. 1996 Jan;103(1):133-40 - PubMed
  49. Lancet. 1971 Mar 27;1(7700):630-3 - PubMed
  50. J Immunol. 1982 May;128(5):2228-35 - PubMed
  51. Cell Immunol. 1987 Mar;105(1):75-85 - PubMed
  52. J Neuroimmunol. 1987 Jun;15(2):185-94 - PubMed
  53. J Immunol. 1981 Apr;126(4):1355-9 - PubMed
  54. J Clin Invest. 2006 Nov;116(11):2843-54 - PubMed
  55. Immunome Res. 2007 Dec 14;3:10 - PubMed
  56. Mol Immunol. 2008 Jul;45(12):3477-89 - PubMed
  57. J Neuroimmunol. 2011 Aug 15;237(1-2):87-92 - PubMed
  58. PLoS One. 2012;7(5):e38028 - PubMed

Publication Types