Display options
Cite
Wang D, Chen Y, Liu JT. A liquid optical phantom with tissue-like heterogeneities for confocal microscopy. Biomed Opt Express. 2012;3(12):3153-60doi: 10.1364/BOE.3.003153.
Wang, D., Chen, Y., & Liu, J. T. (2012). A liquid optical phantom with tissue-like heterogeneities for confocal microscopy. Biomedical optics express, 3(12), 3153-60. https://doi.org/10.1364/BOE.3.003153
Wang, Danni, et al. "A liquid optical phantom with tissue-like heterogeneities for confocal microscopy." Biomedical optics express vol. 3,12 (2012): 3153-60. doi: https://doi.org/10.1364/BOE.3.003153
Wang D, Chen Y, Liu JT. A liquid optical phantom with tissue-like heterogeneities for confocal microscopy. Biomed Opt Express. 2012 Dec 01;3(12):3153-60. doi: 10.1364/BOE.3.003153. Epub 2012 Nov 07. PMID: 23243566; PMCID: PMC3521309.
Copy Download .nbib Format: NLM
Share it on

Biomed Opt Express. 2012 Dec 01;3(12):3153-60. doi: 10.1364/BOE.3.003153. Epub 2012 Nov 07.

A liquid optical phantom with tissue-like heterogeneities for confocal microscopy.

Biomedical optics express

Danni Wang, Ye Chen, Jonathan T C Liu

Affiliations

  1. Stony Brook University (SUNY), Department of Biomedical Engineering, Stony Brook, NY 11794, USA.

PMID: 23243566 PMCID: PMC3521309 DOI: 10.1364/BOE.3.003153

Abstract

Phantoms play an important role in the development, standardization, and calibration of biomedical imaging devices in laboratory and clinical settings, serving as standards to assess the performance of such devices. Here we present the design of a liquid optical phantom to facilitate the assessment of optical-sectioning microscopes that are being developed to enable point-of-care pathology. This phantom, composed of silica microbeads in an Intralipid base, is specifically designed to characterize a reflectance-based dual-axis confocal (DAC) microscope for skin imaging. The phantom mimics the scattering properties of normal human epithelial tissue in terms of an effective scattering coefficient and a depth-dependent degradation in spatial resolution due to beam steering caused by tissue micro-architectural heterogeneities.

Keywords: (170.1790) Confocal microscopy; (170.3880) Medical and biological imaging; (170.5810) Scanning microscopy; (170.6900) Three-dimensional microscopy; (170.7050) Turbid media

References

  1. Biomed Opt Express. 2012 Jun 1;3(6):1381-98 - PubMed
  2. Ann Biomed Eng. 2012 Feb;40(2):378-97 - PubMed
  3. J Biomed Opt. 2006 Jul-Aug;11(4):041103 - PubMed
  4. Opt Express. 2010 Nov 8;18(23):24229-44 - PubMed
  5. Lasers Surg Med. 1992;12(5):510-9 - PubMed
  6. Biomed Opt Express. 2012 Jun 1;3(6):1350-64 - PubMed
  7. J Biomed Opt. 2008 May-Jun;13(3):034020 - PubMed
  8. Opt Lett. 2012 Jun 15;37(12):2430-2 - PubMed
  9. J Biomed Opt. 2006 Sep-Oct;11(5):054019 - PubMed
  10. Nat Commun. 2012 Jan 17;3:632 - PubMed
  11. Appl Opt. 1991 Nov 1;30(31):4507-14 - PubMed
  12. J Biomed Opt. 2006 Jul-Aug;11(4):041102 - PubMed
  13. Opt Lett. 2006 Apr 1;31(7):942-4 - PubMed
  14. Opt Lett. 2004 Nov 15;29(22):2617-9 - PubMed
  15. Biomed Opt Express. 2012 Jun 1;3(6):1326-39 - PubMed
  16. Biomed Opt Express. 2012 Jun 1;3(6):1162-72 - PubMed
  17. Nat Photonics. 2011 Mar;5(3):154 - PubMed
  18. Phys Med Biol. 2011 Jan 21;56(2):N21-8 - PubMed
  19. Nat Commun. 2012 Jun 26;3:928 - PubMed
  20. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:3231-3 - PubMed
  21. Phys Med Biol. 1997 Oct;42(10):1971-9 - PubMed
  22. BMC Med Imaging. 2009 Nov 19;9:19 - PubMed
  23. Anal Cell Pathol (Amst). 2011;34(3):81-98 - PubMed
  24. Biomed Opt Express. 2012 Jun 1;3(6):1399-403 - PubMed

Publication Types

Grant support