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Zubizarreta L, Perrone R, Stoddard PK, et al. Differential serotonergic modulation of two types of aggression in weakly electric fish. Front Behav Neurosci. 2012;6:77doi: 10.3389/fnbeh.2012.00077.
Zubizarreta, L., Perrone, R., Stoddard, P. K., Costa, G., & Silva, A. C. (2012). Differential serotonergic modulation of two types of aggression in weakly electric fish. Frontiers in behavioral neuroscience, 677. https://doi.org/10.3389/fnbeh.2012.00077
Zubizarreta, Lucía, et al. "Differential serotonergic modulation of two types of aggression in weakly electric fish." Frontiers in behavioral neuroscience vol. 6 (2012): 77. doi: https://doi.org/10.3389/fnbeh.2012.00077
Zubizarreta L, Perrone R, Stoddard PK, Costa G, Silva AC. Differential serotonergic modulation of two types of aggression in weakly electric fish. Front Behav Neurosci. 2012 Nov 19;6:77. doi: 10.3389/fnbeh.2012.00077. eCollection 2012. PMID: 23181014; PMCID: PMC3500767.
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Front Behav Neurosci. 2012 Nov 19;6:77. doi: 10.3389/fnbeh.2012.00077. eCollection 2012.

Differential serotonergic modulation of two types of aggression in weakly electric fish.

Frontiers in behavioral neuroscience

Lucía Zubizarreta, Rossana Perrone, Philip K Stoddard, Gustavo Costa, Ana C Silva

Affiliations

  1. Unidad Bases Neurales de la Conducta, Instituto de Investigaciones Biológicas Clemente Estable Montevideo, Uruguay.

PMID: 23181014 PMCID: PMC3500767 DOI: 10.3389/fnbeh.2012.00077

Abstract

Agonistic aggression has provided an excellent framework to study how conserved circuits and neurochemical mediators control species-specific and context-dependent behavior. The principal inhibitory control upon aggression is serotonin (5-HT) dependent, and the activation of 5-HT(1A) receptors is involved in its action. To address whether the serotonergic system differentially regulates different types of aggression, we used two species of weakly electric fish: the solitary Gymnotus omarorum and the gregarious Brachyhypopomus gauderio, which display distinctive types of aggression as part of each species' natural behavioral repertoire. We found that in the reproduction-related aggression displayed by B. gauderio after conflict resolution, the serotonergic activity follows the classic pattern in which subordinates exhibit higher 5-HT levels than controls. After the territorial aggression displayed by G. omarorum, however, both dominants and subordinates show lower 5-HT levels than controls, indicating a different response of the serotonergic system. Further, we found interspecific differences in basal serotonin turnover and in the dynamic profile of the changes in 5-HT levels from pre-contest to post-contest. Finally, we found the expected reduction of aggression and outcome shift in the territorial aggression of G. omarorum after 8-OH-DPAT (5-HT(1A) receptor agonist) administration, but no effect in the reproduction-related aggression of B. gauderio. Our results demonstrate the differential participation of the serotonergic system in the modulation of two types of aggression that we speculate may be a general strategy of the neuroendocrine control of aggression across vertebrates.

Keywords: 5-HT; Brachyhypopomus gauderio; Gymnotus omarorum; agonistic behavior; reproduction-related aggression; territorial aggression

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