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He Q, Ma C, Hu X, et al. Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning. Anal Chem. 2013;85(3):1327-31doi: 10.1021/ac303138x.
He, Q., Ma, C., Hu, X., & Chen, H. (2013). Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning. Analytical chemistry, 85(3), 1327-31. https://doi.org/10.1021/ac303138x
He, Qiaohong, et al. "Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning." Analytical chemistry vol. 85,3 (2013): 1327-31. doi: https://doi.org/10.1021/ac303138x
He Q, Ma C, Hu X, Chen H. Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning. Anal Chem. 2013 Feb 05;85(3):1327-31. doi: 10.1021/ac303138x. Epub 2013 Jan 07. PMID: 23244032.
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Anal Chem. 2013 Feb 05;85(3):1327-31. doi: 10.1021/ac303138x. Epub 2013 Jan 07.

Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning.

Analytical chemistry

Qiaohong He, Cuicui Ma, Xianqiao Hu, Hengwu Chen

Affiliations

  1. Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Zijin'gang Campus, Hangzhou 310058, China. [email protected]

PMID: 23244032 DOI: 10.1021/ac303138x

Abstract

This work presents a novel and facile method for fabricating paper-based microfluidic devices by means of coupling of hydrophobic silane to paper fibers followed by deep UV-lithography. After filter paper being simply immersed in an octadecyltrichlorosilane (OTS) solution in n-hexane for 5 min, the hydrophilic paper became highly hydrophobic (water contact angle of about 125°) due to the hydrophobic OTS molecules were coupled to paper's cellulose fibers. The hydrophobized paper was then exposed to deep UV-lights through a quartz mask that had the pattern of the to-be-prepared channel network. Thus, the UV-exposed regions turned highly hydrophilic whereas the masked regions remained highly hydrophobic, generating hydrophilic channels, reservoirs and reaction zones that were well-defined by the hydrophobic regions. The resolution for hydrophilic channels was 233 ± 30 μm and that for between-channel hydrophobic barrier was 137 ± 21 μm. Contact angle measurement, X-ray photoelectron spectroscopy (XPS) and attenuated total reflectance Fourier transform-infrared (ATR-FT-IR) spectroscopy were employed to characterize the surface chemistry of the OTS-coated and UV/O(3)-treated paper, and the related mechanism was discussed. Colorimetric assays of nitrite are demonstrated with the developed paper-based microfluidic devices.

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