Case Rep Pathol. 2012;2012:284064. doi: 10.1155/2012/284064. Epub 2012 Nov 19.

Dome-type: a distinctive variant of colonic adenocarcinoma.

Case reports in pathology

Giacomo Puppa, Mariella Molaro

PMID: 23213588 PMCID: PMC3507079 DOI: 10.1155/2012/284064

Abstract

Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.

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