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Lenz M, Gardel ML, Dinner AR. Requirements for contractility in disordered cytoskeletal bundles. New J Phys. 2012;14doi: 10.1088/1367-2630/14/3/033037.
Lenz, M., Gardel, M. L., & Dinner, A. R. (2012). Requirements for contractility in disordered cytoskeletal bundles. New journal of physics, 14. https://doi.org/10.1088/1367-2630/14/3/033037
Lenz, Martin, et al. "Requirements for contractility in disordered cytoskeletal bundles." New journal of physics vol. 14 (2012). doi: https://doi.org/10.1088/1367-2630/14/3/033037
Lenz M, Gardel ML, Dinner AR. Requirements for contractility in disordered cytoskeletal bundles. New J Phys. 2012 Mar 01;14. doi: 10.1088/1367-2630/14/3/033037. Epub 2012 Mar 28. PMID: 23155355; PMCID: PMC3496381.
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New J Phys. 2012 Mar 01;14. doi: 10.1088/1367-2630/14/3/033037. Epub 2012 Mar 28.

Requirements for contractility in disordered cytoskeletal bundles.

New journal of physics

Martin Lenz, Margaret L Gardel, Aaron R Dinner

Affiliations

  1. James Franck Institute, University of Chicago, Chicago, IL 60637, USA.

PMID: 23155355 PMCID: PMC3496381 DOI: 10.1088/1367-2630/14/3/033037

Abstract

Actomyosin contractility is essential for biological force generation, and is well understood in highly organized structures such as striated muscle. Additionally, actomyosin bundles devoid of this organization are known to contract both in vivo and in vitro, which cannot be described by standard muscle models. To narrow down the search for possible contraction mechanisms in these systems, we investigate their microscopic symmetries. We show that contractile behavior requires non-identical motors that generate large-enough forces to probe the nonlinear elastic behavior of F-actin. This suggests a role for filament buckling in the contraction of these bundles, consistent with recent experimental results on reconstituted actomyosin bundles.

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