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Sharma HO, Sharma SK. A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India. Indian J Clin Biochem. 1997;12(1):45-8doi: 10.1007/BF02867954.
Sharma, H. O., & Sharma, S. K. (1997). A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India. Indian journal of clinical biochemistry : IJCB, 12(1), 45-8. https://doi.org/10.1007/BF02867954
Sharma, H O, and Sharma, S K. "A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India." Indian journal of clinical biochemistry : IJCB vol. 12,1 (1997): 45-8. doi: https://doi.org/10.1007/BF02867954
Sharma HO, Sharma SK. A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India. Indian J Clin Biochem. 1997 Dec;12(1):45-8. doi: 10.1007/BF02867954. PMID: 23100862; PMCID: PMC3454048.
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Indian J Clin Biochem. 1997 Dec;12(1):45-8. doi: 10.1007/BF02867954.

A comparative study on the effects of Gemfibrozil, Diltiazem and Isosorbide dinitrate on lipid profile in patients of ischemic heart disease in India.

Indian journal of clinical biochemistry : IJCB

H O Sharma, S K Sharma

Affiliations

  1. Department of Biochemistry, M.P. Shah Medical College, 361 008 Jamnagar, Gujarat.

PMID: 23100862 PMCID: PMC3454048 DOI: 10.1007/BF02867954

Abstract

Effects of three drugs, Gemfibrozil, Diltiazem and lsosorbide dinitrate (ISDN) on various lipid parameters were studied in patients with ischemic heart disease (IHD) with positive treadmill stress response. Gemfibrozil and diltiazem significantly lowered the levels of serum total lipids (TL), triglycerides (TG), phospholipids (PL), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), and incroased the levels of serum high density lipoprotein cholesterol (HDL-C) significantly. However, patients administered with ISDN showed a significant increase in all the lipid parameters except HDL-C, which showed a significant decrease.

Keywords: Diltiazem; Gemfibrozil; Ischemic heart disease; Isosorbide dinitrate; Lipid profile

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