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Bhagwat R, Joshi SP, Salgia P, et al. Lipid abnormalities in chronic renal failure. Indian J Clin Biochem. 1997;12(1):81-5doi: 10.1007/BF02867962.
Bhagwat, R., Joshi, S. P., Salgia, P., & Sepaha, A. (1997). Lipid abnormalities in chronic renal failure. Indian journal of clinical biochemistry : IJCB, 12(1), 81-5. https://doi.org/10.1007/BF02867962
Bhagwat, R, et al. "Lipid abnormalities in chronic renal failure." Indian journal of clinical biochemistry : IJCB vol. 12,1 (1997): 81-5. doi: https://doi.org/10.1007/BF02867962
Bhagwat R, Joshi SP, Salgia P, Sepaha A. Lipid abnormalities in chronic renal failure. Indian J Clin Biochem. 1997 Dec;12(1):81-5. doi: 10.1007/BF02867962. PMID: 23100870; PMCID: PMC3454047.
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Indian J Clin Biochem. 1997 Dec;12(1):81-5. doi: 10.1007/BF02867962.

Lipid abnormalities in chronic renal failure.

Indian journal of clinical biochemistry : IJCB

R Bhagwat, S P Joshi, P Salgia, A Sepaha

Affiliations

  1. Department of Pathology, Choithram Hospital & Research Centre, Manik Bay Road, 452 001 Indore.

PMID: 23100870 PMCID: PMC3454047 DOI: 10.1007/BF02867962

Abstract

Lipid abnormalities remain to be a major cause of early mortality in patients with chronic renal failure (CRF). In present study, 114 (one hundred fourteen) CRF patients without any additional cause of dyslipidemia were divided into groups on the basis of etiologies of CRF. Blood samples from each group were analyzed for total cholesterol, triglyceride and HDL cholesterol along with blood urea nitrogen and serum creatinine. 25 healthy individuals without any obvious disease were taken as control. Patients from all the groups showed a marked hypertriglyceridemia of 232 (SD±77) mg/dl (P<0.001) as compared to control. Levels of HDL cholesterol were found to be significantly low 20 (±11) mg/dl (p<0.001) in all the groups. LDL cholesterol showed an increase 104 (±30) mg/dl as compared to control group which is not statistically significant. Present study reveals that, CRF patients show an uniform dyslipidemia irrespective of etiologies leading to CRF. This dyslipidemia is also independent of serum creatinine levels. Although, these lipid abnormalities may not solely cause mortality in CRF patients, they may act as modulators in accelerating atherogenesis which in turn cause early mortality in CRF patients.

Keywords: Atherogenesis; Chronic Renal Failure (CRF); Dyslipidemia; High Density Lipids (HDL); Low Desity Lipids (LDL)

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