Display options
Cite
Gupta A, Nair S, Schweitzer AD, et al. Neuroimaging of cerebrovascular disease in the aging brain. Aging Dis. 2012;3(5):414-25
Gupta, A., Nair, S., Schweitzer, A. D., Kishore, S., Johnson, C. E., Comunale, J. P., Tsiouris, A. J., & Sanelli, P. C. (2012). Neuroimaging of cerebrovascular disease in the aging brain. Aging and disease, 3(5), 414-25.
Gupta, Ajay, et al. "Neuroimaging of cerebrovascular disease in the aging brain." Aging and disease vol. 3,5 (2012): 414-25.
Gupta A, Nair S, Schweitzer AD, Kishore S, Johnson CE, Comunale JP, Tsiouris AJ, Sanelli PC. Neuroimaging of cerebrovascular disease in the aging brain. Aging Dis. 2012 Oct;3(5):414-25. Epub 2012 Sep 19. PMID: 23185721; PMCID: PMC3501396.
Copy Download .nbib Format: NLM
Share it on

Aging Dis. 2012 Oct;3(5):414-25. Epub 2012 Sep 19.

Neuroimaging of cerebrovascular disease in the aging brain.

Aging and disease

Ajay Gupta, Sreejit Nair, Andrew D Schweitzer, Sirish Kishore, Carl E Johnson, Joseph P Comunale, Apostolos J Tsiouris, Pina C Sanelli

Affiliations

  1. Department of Radiology, Weill Cornell Medical College, New York Presbyterian Hospital, New York, USA.

PMID: 23185721 PMCID: PMC3501396

Abstract

Cerebrovascular disease remains a significant public health burden with its greatest impact on the elderly population. Advances in neuroimaging techniques allow detailed and sophisticated evaluation of many manifestations of cerebrovascular disease in the brain parenchyma as well as in the intracranial and extracranial vasculature. These tools continue to contribute to our understanding of the multifactorial processes that occur in the age-dependent development of cerebrovascular disease. Structural abnormalities related to vascular disease in the brain and vessels have been well characterized with CT and MRI based techniques. We review some of the pathophysiologic mechanisms in the aging brain and cerebral vasculature and the related structural abnormalities detectable on neuroimaging, including evaluation of age-related white matter changes, atherosclerosis of the cerebral vasculature, and cerebral infarction. In addition, newer neuroimaging techniques, such as diffusion tensor imaging, perfusion techniques, and assessment of cerebrovascular reserve, are also reviewed, as these techniques can detect physiologic alterations which complement the morphologic changes that cause cerebrovascular disease in the aging brain.Further investigation of these advanced imaging techniques has potential application to the understanding and diagnosis of cerebrovascular disease in the elderly.

Keywords: Neuroradiology; aging; cerebral infarction; cerebrovascular disease; neuroimaging; white matter

References

  1. JAMA. 2000 Apr 26;283(16):2122-7 - PubMed
  2. Neurobiol Aging. 2012 Jan;33(1):75-82 - PubMed
  3. J Neurol Neurosurg Psychiatry. 2001 Jan;70(1):9-14 - PubMed
  4. Neurology. 1982 Aug;32(8):871-6 - PubMed
  5. Ann Neurol. 2007 Jun;61(6):533-43 - PubMed
  6. J Cereb Blood Flow Metab. 2007 Sep;27(9):1563-72 - PubMed
  7. Acad Radiol. 2001 Oct;8(10):955-64 - PubMed
  8. Brain Res Brain Res Protoc. 2004 Feb;12(3):137-43 - PubMed
  9. Vasc Med. 2007 Nov;12(4):329-41 - PubMed
  10. Ann Nucl Med. 1996 Aug;10(3):293-8 - PubMed
  11. Stroke. 2011 Sep;42(9):2550-5 - PubMed
  12. Biol Psychiatry. 2008 Aug 15;64(4):273-80 - PubMed
  13. Int Angiol. 2006 Dec;25(4):385-8 - PubMed
  14. Neurology. 2012 Jul 31;79(5):442-8 - PubMed
  15. Stroke. 2002 Jan;33(1):45-50 - PubMed
  16. J Cereb Blood Flow Metab. 2002 Sep;22(9):1142-8 - PubMed
  17. Stroke. 2010 Oct;41(10 Suppl):S12-6 - PubMed
  18. Stroke. 2008 Apr;39(4):1184-8 - PubMed
  19. Neuroimage. 2011 Mar 15;55(2):468-78 - PubMed
  20. Neurology. 1994 Jul;44(7):1246-52 - PubMed
  21. Stroke. 2006 Apr;37(4):1010-5 - PubMed
  22. Top Stroke Rehabil. 2004 Spring;11(2):23-32 - PubMed
  23. Neurotox Res. 2003;5(7):491-504 - PubMed
  24. Circ J. 2010 Nov;74(11):2257-62 - PubMed
  25. J Neurol Neurosurg Psychiatry. 2011 Feb;82(2):126-35 - PubMed
  26. Semin Roentgenol. 2010 Apr;45(2):116-25 - PubMed
  27. AJR Am J Roentgenol. 2012 Jan;198(1):63-74 - PubMed
  28. Rev Neurol (Paris). 2008 Oct;164(10):793-800 - PubMed
  29. Neurology. 2010 Jul 13;75(2):177-85 - PubMed
  30. Stroke Res Treat. 2012;2012:839151 - PubMed
  31. AJNR Am J Neuroradiol. 2008 Nov;29(10):1831-6 - PubMed
  32. J Neurol. 2008 Aug;255(8):1182-9 - PubMed
  33. Stroke. 2012 Jul;43(7):1878-84 - PubMed
  34. Vasc Med. 2008 Nov;13(4):281-92 - PubMed
  35. Neuroimaging Clin N Am. 2005 May;15(2):367-81, xi - PubMed
  36. Stroke. 1996 Mar;27(3):373-80 - PubMed
  37. Stroke. 1997 Jul;28(7):1507-17 - PubMed
  38. Neuroepidemiology. 1997;16(3):149-62 - PubMed
  39. Arch Neurol. 2006 Sep;63(9):1287-91 - PubMed
  40. Brain. 2001 Mar;124(Pt 3):457-67 - PubMed
  41. Stroke. 1999 Feb;30(2):393-7 - PubMed
  42. Neurobiol Aging. 2005 Aug-Sep;26(8):1215-27 - PubMed
  43. Lancet. 2007 Jan 27;369(9558):293-8 - PubMed
  44. Stroke. 2005 Jan;36(1):50-5 - PubMed
  45. Stroke. 2004 Nov;35(11):2477-83 - PubMed
  46. Alzheimers Dement. 2009 Nov;5(6):454-62 - PubMed
  47. Neurology. 2011 Jul 5;77(1):55-61 - PubMed
  48. Stroke. 1992 Nov;23(11):1551-5 - PubMed
  49. Stroke. 1997 Feb;28(2):459-63 - PubMed
  50. Stroke. 1999 Mar;30(3):593-8 - PubMed
  51. J Neurol Sci. 1993 Jan;114(1):7-12 - PubMed
  52. Stroke. 1994 Apr;25(4):808-13 - PubMed
  53. Front Med. 2012 Mar;6(1):22-34 - PubMed
  54. Neurobiol Aging. 2012 Jun;33(6):1127.e1-9 - PubMed
  55. Med Health R I. 2009 Dec;92(12):412-4 - PubMed
  56. Natl Vital Stat Rep. 2011 Dec 7;59(10):1-126 - PubMed
  57. Radiology. 2003 Sep;228(3):677-82 - PubMed
  58. Circulation. 2011 Feb 1;123(4):e18-e209 - PubMed
  59. Radiographics. 2005 Nov-Dec;25(6):1561-75 - PubMed
  60. Pract Neurol. 2008 Feb;8(1):26-38 - PubMed
  61. Neurology. 2010 Nov 9;75(19):1670-7 - PubMed
  62. J Neuropsychiatry Clin Neurosci. 2005 Fall;17(4):533-40 - PubMed
  63. AJR Am J Roentgenol. 2009 Feb;192(2):W63-70 - PubMed
  64. J Vasc Surg. 1995 Feb;21(2):338-44; discussion 344-5 - PubMed

Publication Types