Display options
Cite
Yang JC, Park JI, Kim GW, et al. Effects of antidepressant treatment on sexual arousal in depressed women: a preliminary FMRI study. Psychiatry Investig. 2012;9(4):379-83doi: 10.4306/pi.2012.9.4.379.
Yang, J. C., Park, J. I., Kim, G. W., Eun, S. J., Lee, M. S., Han, K. L., Chae, J. H., & Jeong, G. W. (2012). Effects of antidepressant treatment on sexual arousal in depressed women: a preliminary FMRI study. Psychiatry investigation, 9(4), 379-83. https://doi.org/10.4306/pi.2012.9.4.379
Yang, Jong-Chul, et al. "Effects of antidepressant treatment on sexual arousal in depressed women: a preliminary FMRI study." Psychiatry investigation vol. 9,4 (2012): 379-83. doi: https://doi.org/10.4306/pi.2012.9.4.379
Yang JC, Park JI, Kim GW, Eun SJ, Lee MS, Han KL, Chae JH, Jeong GW. Effects of antidepressant treatment on sexual arousal in depressed women: a preliminary FMRI study. Psychiatry Investig. 2012 Dec;9(4):379-83. doi: 10.4306/pi.2012.9.4.379. Epub 2012 Nov 12. PMID: 23251203; PMCID: PMC3521115.
Copy Download .nbib Format: NLM
Share it on

Psychiatry Investig. 2012 Dec;9(4):379-83. doi: 10.4306/pi.2012.9.4.379. Epub 2012 Nov 12.

Effects of antidepressant treatment on sexual arousal in depressed women: a preliminary FMRI study.

Psychiatry investigation

Jong-Chul Yang, Jong-Il Park, Gwang-Won Kim, Sung-Jong Eun, Moo-Suk Lee, Kyung-Lae Han, Jeong-Ho Chae, Gwang-Woo Jeong

Affiliations

  1. Department of Psychiatry, Chonbuk National University Medical School and Institute for Medical Sciences, Jeonju, Republic of Korea. ; Department of Psychiatry, Chonbuk National University Hospital and Research Institute of Clinical Medicine, Jeonju, Republic of Korea.

PMID: 23251203 PMCID: PMC3521115 DOI: 10.4306/pi.2012.9.4.379

Abstract

OBJECTIVE: There was a recent study to explore the cerebral regions associated with sexual arousal in depressed women using functional magnetic resonance imaging (fMRI). The purpose of this neuroimaging study was to investigate the effects of antidepressant treatment on sexual arousal in depressed women.

METHODS: SEVEN DEPRESSED WOMEN WITH SEXUAL AROUSAL DYSFUNCTION (MEAN AGE: 41.7±13.8, mean scores of the Beck Depression Inventory (BDI) and the 17-item Hamilton Rating Scale for Depression (HAMD-17): 35.6±7.1 and 34.9±3.1, respectively) and nine healthy women (mean age: 40.3±11.6) underwent fMRI before and after antidepressant treatment. The fMRI paradigm contrasted a 1 minute rest period viewing non-erotic film with 4 minutes of sexual stimulation viewing an erotic video film. Data were analyzed by SPM 2. The relative number of pixels activated in each period was used as an index of activation. All depressed women were treated with mirtazapine (mean dosage: 37.5 mg/day) for 8 to 10 weeks.

RESULTS: Levels of brain activity during sexual arousal in depressed women significantly increased with antidepressant treatment (p<0.05) in the regions of the hypothalamus (3.0% to 11.2%), septal area (8.6% to 27.8%) and parahippocampal gyrus (5.8% to 14.6%). Self-reported sexual arousal during visual sexual stimulation also significantly increased post-treatment, and severity of depressive symptoms improved, as measured by the BDI and HAMD-17 (p<0.05).

CONCLUSION: These results show that sexual arousal dysfunction of depressed women may improve after treatment of depression, and that this improvement is associated with increased activation of the hypothalamus, septal area, and parahippocampal gyrus during sexual arousal.

Keywords: Cerebral region; Depression; Functional magnetic resonance imaging (fMRI); Sexual arousal; Treatment; Women

References

  1. Biol Psychiatry. 1988 May;24(1):33-46 - PubMed
  2. Ann Pharmacother. 2002 Oct;36(10):1577-89 - PubMed
  3. Am J Psychiatry. 1981 Jan;138(1):1-13 - PubMed
  4. Hum Brain Mapp. 2000 Nov;11(3):162-77 - PubMed
  5. Hum Psychopharmacol. 2008 Jun;23(4):321-6 - PubMed
  6. Urology. 2001 Jun;57(6):1189-94 - PubMed
  7. Arch Gen Psychiatry. 1985 Nov;42(11):1098-104 - PubMed
  8. Hum Brain Mapp. 2002 May;16(1):1-13 - PubMed
  9. Neuropsychobiology. 1982;8(6):284-8 - PubMed
  10. Int Clin Psychopharmacol. 1995 Dec;10 Suppl 4:37-45 - PubMed
  11. BMJ. 1999 Dec 11;319(7224):1551-4 - PubMed
  12. Psychiatry Investig. 2009 Jun;6(2):85-95 - PubMed
  13. Horm Behav. 1990 Sep;24(3):421-34 - PubMed
  14. Arch Sex Behav. 1999 Feb;28(1):1-21 - PubMed
  15. Pharmacopsychiatry. 2007 Mar;40(2):58-63 - PubMed
  16. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5517-21 - PubMed
  17. Neuroscience. 2003;122(3):599-607 - PubMed
  18. Arch Gen Psychiatry. 1961 Jun;4:561-71 - PubMed
  19. Int Clin Psychopharmacol. 1999 Jul;14(4):253-5 - PubMed
  20. J Sex Med. 2008 Mar;5(3):602-9 - PubMed
  21. AJNR Am J Neuroradiol. 2008 Nov;29(10):1890-6 - PubMed
  22. Int J Impot Res. 2001 Apr;13(2):73-81 - PubMed
  23. J Neurosci. 1989 Feb;9(2):497-506 - PubMed
  24. J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 - PubMed
  25. Korean J Radiol. 2004 Apr-Jun;5(2):87-95 - PubMed
  26. Am J Psychiatry. 1999 May;156(5):671-3 - PubMed
  27. Arch Sex Behav. 1982 Aug;11(4):323-8 - PubMed
  28. J Affect Disord. 1987 Jul-Aug;13(1):61-6 - PubMed

Publication Types