Indian J Clin Biochem. 1999 Jan;14(1):59-90. doi: 10.1007/BF02869152.
Indian journal of clinical biochemistry : IJCB
P L Wolf
PMID: 23105203 PMCID: PMC3453559 DOI: 10.1007/BF02869152
It is important that clinicians and laboratorians, including clinical chemists and pathologists, recognize and understand the clinical significance of abnormal liver function tests. The liver regulates many important metabolic functions. Hepatic injury is associated with distortion of these metabolic functions. Hepatic disease can be evaluated and diagnosed by determining serum concentrations of a number of serum analytes. Many serum analytes exist to assist in the biochemical diagnosis of liver disease. The focus of this paper is on the analytes which are associated with hepatic necrosis, cholestasis, defects in excretion and end stage hepatic disease which results in decreased synthetic function. The abnormalities of these serum analytes will be correlated with the important types of liver disease.
Keywords: Liver function tests; albumin; alkaline phosphatase and transaminases; bilirubin