Display options
Cite
Malati T, Yadagiri B, Krishna DM, et al. Spectrum of monoclonal gammapathies in Andhra Pradesh. Indian J Clin Biochem. 2001;16(1):52-9doi: 10.1007/BF02867568.
Malati, T., Yadagiri, B., Krishna, D. M., Shantaram, V., Raghunadharao, D., & Subbarao, K. (2001). Spectrum of monoclonal gammapathies in Andhra Pradesh. Indian journal of clinical biochemistry : IJCB, 16(1), 52-9. https://doi.org/10.1007/BF02867568
Malati, T, et al. "Spectrum of monoclonal gammapathies in Andhra Pradesh." Indian journal of clinical biochemistry : IJCB vol. 16,1 (2001): 52-9. doi: https://doi.org/10.1007/BF02867568
Malati T, Yadagiri B, Krishna DM, Shantaram V, Raghunadharao D, Subbarao K. Spectrum of monoclonal gammapathies in Andhra Pradesh. Indian J Clin Biochem. 2001 Jan;16(1):52-9. doi: 10.1007/BF02867568. PMID: 23105292; PMCID: PMC3453618.
Copy Download .nbib Format: NLM
Share it on

Indian J Clin Biochem. 2001 Jan;16(1):52-9. doi: 10.1007/BF02867568.

Spectrum of monoclonal gammapathies in Andhra Pradesh.

Indian journal of clinical biochemistry : IJCB

T Malati, B Yadagiri, D M Krishna, V Shantaram, D Raghunadharao, K Subbarao

Affiliations

  1. Department of Biochemistry, Nizam's Institute of Medical Sciences, Punjagutta, 500 082 Hyderabad, Andhra Pradesh India.

PMID: 23105292 PMCID: PMC3453618 DOI: 10.1007/BF02867568

Abstract

In the present study, monoclonal gammapathy was identified in a total of 245 patients of plasma cell dyscrasias during period of 1987 to 2000. The monoclonal band was identified in serum by agar gel electrophoresis in all the cases and in urine in a few cases. Characterization of paraprotein (monoclonal immunoglobulin class and light chain type) was carried out by employing immunoelectrophoresis and/or immunofixation electrophoresis using heavy chain specific gamma, alpha, mu, delta and epsilon and light chain specific kappa (K), lambda (λ) antisera. Serum immunoglobulins Ig G, Ig A, and Ig M were estimated by immunoturbidometry. Serum urea, creatinine, uric acid, alkaline phosphatase, total proteins, albumin, calcium and phosphorus were estimated by using routine biochemical methods. Among the 245 cases, 73.1% monoclonal gammapathies were of secretory type and 7.3% were non-secretory. Monoclonal gammapathies were associated with 80.4% of multiple myeloma, 8.9% of solitary plasmacytoma, 4.1% of extra-medullary plasmacytoma, 3.3% of lymphoma and 2.9% of plasma cell leukemia. Classification of secretory monoclonal immunoglobulin revealed monoclonal immunoglobulin Ig G in 74%, Ig A 15% and Ig M in 2.9% cases.

Keywords: Monoclonal gammapathies; Monoclonal immunoglobulins; Multiple Myeloma; Praproteins

References

  1. Arch Pathol Lab Med. 1983 Dec;107(12):654-7 - PubMed
  2. Br Med J. 1973 Dec 15;4(5893):643-6 - PubMed
  3. J Assoc Physicians India. 1971 Aug;19(8):563-6 - PubMed
  4. Lancet. 1961 Feb 4;1(7171):237-9 - PubMed
  5. Clin Sci (Lond). 1988 Jun;74(6):607-12 - PubMed
  6. Tex Rep Biol Med. 1965;23:445-57 - PubMed
  7. Blood. 1980 Jun;55(6):1011-9 - PubMed
  8. Blood. 1980 Mar;55(3):364-72 - PubMed
  9. BMJ. 1989 Dec 2;299(6712):1381-2 - PubMed
  10. Clin Chim Acta. 1989 Mar 15;180(1):1-22 - PubMed
  11. Nephron. 1973;10(1):1-24 - PubMed
  12. J Chronic Dis. 1971 Jul;24(4):221-7 - PubMed
  13. N Engl J Med. 1991 Jun 27;324(26):1845-51 - PubMed
  14. Eur J Haematol. 1992 Apr;48(4):192-5 - PubMed
  15. Am J Otolaryngol. 1999 Jul-Aug;20(4):257-9 - PubMed
  16. Semin Oncol. 1986 Sep;13(3):282-90 - PubMed
  17. Semin Roentgenol. 1986 Apr;21(2):139-49 - PubMed
  18. Am J Med Sci. 1976 Sep-Oct;272(2):175-83 - PubMed
  19. N Engl J Med. 1979 Oct 4;301(14):743-8 - PubMed
  20. Medicine (Baltimore). 1980 Sep;59(5):380-92 - PubMed
  21. J Clin Invest. 1964 Jan;43:103-17 - PubMed
  22. Am J Med. 1975 Mar;58(3):354-64 - PubMed
  23. Haematologica. 1994 Nov-Dec;79(6):557-66 - PubMed
  24. J Clin Oncol. 1983 Apr;1(4):255-62 - PubMed
  25. Harvey Lect. 1982-1983;78:1-22 - PubMed
  26. Medicine (Baltimore). 1963 Nov;42:357-84 - PubMed
  27. Lancet. 1961 Feb 4;1(7171):239-45 - PubMed
  28. Semin Oncol. 1999 Oct;26(5 Suppl 13):35-42 - PubMed
  29. Mayo Clin Proc. 1975 Jan;50(1):29-40 - PubMed
  30. Mayo Clin Proc. 1981 Jul;56(7):439-51 - PubMed
  31. Medicine (Baltimore). 1989 Nov;68(6):321-35 - PubMed

Publication Types