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Singh D, Rajeswari MR. Enhanced expression of HMG-Y proteins in proliferating tissues. Indian J Clin Biochem. 2001;16(1):72-6doi: 10.1007/BF02867571.
Singh, D., & Rajeswari, M. R. (2001). Enhanced expression of HMG-Y proteins in proliferating tissues. Indian journal of clinical biochemistry : IJCB, 16(1), 72-6. https://doi.org/10.1007/BF02867571
Singh, D, and Rajeswari, M R. "Enhanced expression of HMG-Y proteins in proliferating tissues." Indian journal of clinical biochemistry : IJCB vol. 16,1 (2001): 72-6. doi: https://doi.org/10.1007/BF02867571
Singh D, Rajeswari MR. Enhanced expression of HMG-Y proteins in proliferating tissues. Indian J Clin Biochem. 2001 Jan;16(1):72-6. doi: 10.1007/BF02867571. PMID: 23105295; PMCID: PMC3453602.
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Indian J Clin Biochem. 2001 Jan;16(1):72-6. doi: 10.1007/BF02867571.

Enhanced expression of HMG-Y proteins in proliferating tissues.

Indian journal of clinical biochemistry : IJCB

D Singh, M R Rajeswari

Affiliations

  1. Department of Biochemistry, All India Institute of Medical Sciences, 110029 New Delhi, India.

PMID: 23105295 PMCID: PMC3453602 DOI: 10.1007/BF02867571

Abstract

The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group, is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer.

Keywords: Cancer; Cell Proliferation; HMG-Y proteins

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