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Rani HS, Madhavi G, Rao VR, et al. Risk factors for coronary heart disease in type II diabetes mellitus. Indian J Clin Biochem. 2005;20(2):75-80doi: 10.1007/BF02867404.
Rani, H. S., Madhavi, G., Rao, V. R., Sahay, B. K., & Jyothy, A. (2005). Risk factors for coronary heart disease in type II diabetes mellitus. Indian journal of clinical biochemistry : IJCB, 20(2), 75-80. https://doi.org/10.1007/BF02867404
Rani, H Surekha, et al. "Risk factors for coronary heart disease in type II diabetes mellitus." Indian journal of clinical biochemistry : IJCB vol. 20,2 (2005): 75-80. doi: https://doi.org/10.1007/BF02867404
Rani HS, Madhavi G, Rao VR, Sahay BK, Jyothy A. Risk factors for coronary heart disease in type II diabetes mellitus. Indian J Clin Biochem. 2005 Jul;20(2):75-80. doi: 10.1007/BF02867404. PMID: 23105537; PMCID: PMC3453836.
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Indian J Clin Biochem. 2005 Jul;20(2):75-80. doi: 10.1007/BF02867404.

Risk factors for coronary heart disease in type II diabetes mellitus.

Indian journal of clinical biochemistry : IJCB

H Surekha Rani, G Madhavi, V Ramachandra Rao, B K Sahay, A Jyothy

Affiliations

  1. Dept. of Cell Biology, Institute of Genetics amd Hospital for Genetic Diseases, Osmania University, Begumpet, 16 Hyderabad.

PMID: 23105537 PMCID: PMC3453836 DOI: 10.1007/BF02867404

Abstract

Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. An attempt has been made to evaluate the risk factors for coronary heart disease in type II diabetics. In the present study the levels of fasting and postprandial plasma glucose, total cholesterol, low density lipoproteins, triglycerides were high and the levels of high density lipoproteins were low in the type II diabetics compared to controls. The markers of free radical induced injury i.e. malondialdehyde and nitrite/nitrate were high while total antioxidant status a marker for antioxidant protection against reactive oxygen species was low in diabetics compared to controls. The study therefore suggests the importance of assessing these markers of oxidative stress and antioxidant capacity along with the other routine investigations in diabetic patients for initiating antioxidant therapy in addition to primary and secondary preventive measures to mitigate the devastating consequences of diabetes leading to coronary heart disease.

Keywords: Coronary Heart Disease; Oxidative stress; Risk factors; Total antioxidant status; Type II Diabetes Mellitus

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